Platelet function in stored heparinised autologous blood is not superior to in patient platelet function during routine cardiopulmonary bypass
In cardiac surgery, cardiopulmonary bypass (CPB) and unfractionated heparin have negative effects on blood platelet function. In acute normovolemic haemodilution autologous unfractionated heparinised blood is stored ex-vivo and retransfused at the end of the procedure to reduce (allogeneic) transfus...
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| creator | Gallandat Huet, Rolf C G de Vries, Adrianus J Cernak, Vladimir Lisman, Ton |
| description | In cardiac surgery, cardiopulmonary bypass (CPB) and unfractionated heparin have negative effects on blood platelet function. In acute normovolemic haemodilution autologous unfractionated heparinised blood is stored ex-vivo and retransfused at the end of the procedure to reduce (allogeneic) transfusion requirements. In this observational study we assessed whether platelet function is better preserved in ex vivo stored autologous blood compared to platelet function in the patient during CPB.
We measured platelet aggregation responses pre-CPB, 5 min after the start of CPB, at the end of CPB, and after unfractionated heparin reversal, using multiple electrode aggregometry (Multiplate®) with adenosine diphosphate (ADP), thrombin receptor activating peptide (TRAP) and ristocetin activated test cells. We compared blood samples taken from the patient with samples taken from 100 ml ex-vivo stored blood, which we took to mimick blood storage during normovolemic haemodilution. Platelet function declined both in ex-vivo stored blood as well as in blood taken from the patient. At the end of CPB there were no differences in platelet aggregation responses between samples from the ex vivo stored blood and the patient.
Ex vivo preservation of autologous blood in unfractionated heparin does not seem to be profitable to preserve platelet function. |
| doi_str_mv | 10.1371/journal.pone.0033686 |
| format | Article |
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We measured platelet aggregation responses pre-CPB, 5 min after the start of CPB, at the end of CPB, and after unfractionated heparin reversal, using multiple electrode aggregometry (Multiplate®) with adenosine diphosphate (ADP), thrombin receptor activating peptide (TRAP) and ristocetin activated test cells. We compared blood samples taken from the patient with samples taken from 100 ml ex-vivo stored blood, which we took to mimick blood storage during normovolemic haemodilution. Platelet function declined both in ex-vivo stored blood as well as in blood taken from the patient. At the end of CPB there were no differences in platelet aggregation responses between samples from the ex vivo stored blood and the patient.
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We measured platelet aggregation responses pre-CPB, 5 min after the start of CPB, at the end of CPB, and after unfractionated heparin reversal, using multiple electrode aggregometry (Multiplate®) with adenosine diphosphate (ADP), thrombin receptor activating peptide (TRAP) and ristocetin activated test cells. We compared blood samples taken from the patient with samples taken from 100 ml ex-vivo stored blood, which we took to mimick blood storage during normovolemic haemodilution. Platelet function declined both in ex-vivo stored blood as well as in blood taken from the patient. At the end of CPB there were no differences in platelet aggregation responses between samples from the ex vivo stored blood and the patient.
Ex vivo preservation of autologous blood in unfractionated heparin does not seem to be profitable to preserve platelet function.</description><subject>Adenosine</subject><subject>Adenosine diphosphate</subject><subject>Aged</subject><subject>Agglomeration</subject><subject>Anesthesiology</subject><subject>Anticoagulants</subject><subject>Anticoagulants - pharmacology</subject><subject>ATPases</subject><subject>Blood</subject><subject>Blood platelets</subject><subject>Blood Platelets - metabolism</subject><subject>Blood Preservation</subject><subject>Blood tests</subject><subject>Blood Transfusion, Autologous</subject><subject>Cardiopulmonary Bypass</subject><subject>Coronary artery bypass</subject><subject>Coronary vessels</subject><subject>Electrodes</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Heart surgery</subject><subject>Heparin</subject><subject>Heparin - pharmacology</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Platelet aggregation</subject><subject>Platelet Function Tests</subject><subject>Preservation</subject><subject>Ristocetin</subject><subject>Surgery</subject><subject>Thrombin</subject><subject>Thrombosis</subject><subject>Transfusion</subject><subject>Veins & arteries</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsIYG42MWOvU72BqmqOKxUqYjTreXYk6wrr53aDqIvwTPjsGm1gV6gXGQ8-eYf57enKJ4SvCS0Im8u_RCctMveO1hiTCmv-b3imKxpueAlpvcP4qPiUYyXGK9ozfnD4qgsGSsrgo-LX5-sTGAhoXZwKhnvkHEoJh9Aoy30MhhnYo7lkLz1nR8iaqz3GpmInE8oDj0E4wNKfqzsZTLgEur_kdVDlupQ8EMyDpCSQRvfD3bnnQzXqLnuZYyPiwettBGeTO-T4tv7d1_PPi7OLz5szk7PF4qvSVrISkOl24rIBhRhq7aGVpUrTojinDCtWMNXOb9itawJV5yqsqlKojkG3uTlSfF8r9tbH8VkZRSEZmMoY5xmYrMntJeXog9ml3cpvDTiT8KHTsiQjLIgsK4kV3W9LmXDmho3GBqmoW2rHNAVZK23U7eh2YFW2aAg7Ux0_sWZrej8D0EpripWZ4FXk0DwVwPEJHYmKrBWOsgnItZs7I5LlskXf5F3_9xEdTLv37jW57Zq1BSnrKowZ2s-ai3voPKjYWdUvnatyflZwetZQWYS_EydHGIUmy-f_5-9-D5nXx6wW5A2baO3w3iv4hxke1AFH2OA9tZjgsU4NTduiHFqxDQ1uezZ4fncFt2MCf0NqBkWvw</recordid><startdate>20120319</startdate><enddate>20120319</enddate><creator>Gallandat Huet, Rolf C G</creator><creator>de Vries, Adrianus J</creator><creator>Cernak, Vladimir</creator><creator>Lisman, Ton</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120319</creationdate><title>Platelet function in stored heparinised autologous blood is not superior to in patient platelet function during routine cardiopulmonary bypass</title><author>Gallandat Huet, Rolf C G ; de Vries, Adrianus J ; Cernak, Vladimir ; Lisman, Ton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-a7de7df71abec145f8efc25611c6614dc4b65145548a816c63c2b721d60e6bc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenosine</topic><topic>Adenosine diphosphate</topic><topic>Aged</topic><topic>Agglomeration</topic><topic>Anesthesiology</topic><topic>Anticoagulants</topic><topic>Anticoagulants - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallandat Huet, Rolf C G</au><au>de Vries, Adrianus J</au><au>Cernak, Vladimir</au><au>Lisman, Ton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet function in stored heparinised autologous blood is not superior to in patient platelet function during routine cardiopulmonary bypass</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-03-19</date><risdate>2012</risdate><volume>7</volume><issue>3</issue><spage>e33686</spage><epage>e33686</epage><pages>e33686-e33686</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In cardiac surgery, cardiopulmonary bypass (CPB) and unfractionated heparin have negative effects on blood platelet function. In acute normovolemic haemodilution autologous unfractionated heparinised blood is stored ex-vivo and retransfused at the end of the procedure to reduce (allogeneic) transfusion requirements. In this observational study we assessed whether platelet function is better preserved in ex vivo stored autologous blood compared to platelet function in the patient during CPB.
We measured platelet aggregation responses pre-CPB, 5 min after the start of CPB, at the end of CPB, and after unfractionated heparin reversal, using multiple electrode aggregometry (Multiplate®) with adenosine diphosphate (ADP), thrombin receptor activating peptide (TRAP) and ristocetin activated test cells. We compared blood samples taken from the patient with samples taken from 100 ml ex-vivo stored blood, which we took to mimick blood storage during normovolemic haemodilution. Platelet function declined both in ex-vivo stored blood as well as in blood taken from the patient. At the end of CPB there were no differences in platelet aggregation responses between samples from the ex vivo stored blood and the patient.
Ex vivo preservation of autologous blood in unfractionated heparin does not seem to be profitable to preserve platelet function.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22442710</pmid><doi>10.1371/journal.pone.0033686</doi><tpages>e33686</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine Adenosine diphosphate Aged Agglomeration Anesthesiology Anticoagulants Anticoagulants - pharmacology ATPases Blood Blood platelets Blood Platelets - metabolism Blood Preservation Blood tests Blood Transfusion, Autologous Cardiopulmonary Bypass Coronary artery bypass Coronary vessels Electrodes Female Heart diseases Heart surgery Heparin Heparin - pharmacology Humans Laboratories Male Medicine Middle Aged Observational studies Patients Platelet aggregation Platelet Function Tests Preservation Ristocetin Surgery Thrombin Thrombosis Transfusion Veins & arteries |
| title | Platelet function in stored heparinised autologous blood is not superior to in patient platelet function during routine cardiopulmonary bypass |
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