The evolution of extracellular fibrillins and their functional domains

Fibrillins constitute the major backbone of multifunctional microfibrils in elastic and non-elastic extracellular matrices, and are known to interact with several binding partners including tropoelastin and integrins. Here, we study the evolution of fibrillin proteins. Following sequence collection...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33560
Hauptverfasser:	Piha-Gossack, Adam, Sossin, Wayne, Reinhardt, Dieter P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Analysis Animals Arthropods Binding sites Binding Sites - genetics Biological evolution Biology Biosynthesis C-Terminus Chemical bonds Conserved Sequence Cysteine Elastin Epidermal growth factor Epidermal growth factors Evolution Evolution, Molecular Evolutionary genetics Extracellular matrix Extracellular Matrix Proteins - chemistry Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fibrillin Fibrillin-1 Fibrillin-2 Fibrillins Fibroblasts Furin Gene duplication Genes Genetics Glycine Humans Integrins Integrins - metabolism Invertebrates Likelihood Functions Mammals Microfibrils Microfilament Proteins - chemistry Microfilament Proteins - genetics Microfilament Proteins - metabolism Models, Genetic Models, Molecular Molecular Sequence Data Mollusks Mutation N-Terminus Oligopeptides - chemistry Phylogenetics Phylogeny Proline Protein Precursors - chemistry Protein Precursors - genetics Protein Precursors - metabolism Protein Structure, Tertiary Proteins Reproduction (copying) Sequence Homology, Amino Acid Sequences Species Specificity Trees Tropoelastin Vertebrates
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