Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis

Tuberculosis (TB) remains a leading cause of mortality worldwide. With the emergence of multidrug resistant TB, extensively drug resistant TB and HIV-associated TB it is imperative that new drug targets be identified. The potential of Mycobacterium tuberculosis inosine monophosphate dehydrogenase (I...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33886-e33886
Hauptverfasser:	Usha, Veeraraghavan, Hobrath, Judith V, Gurcha, Sudagar S, Reynolds, Robert C, Besra, Gurdyal S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Animals Antibiotics Antitubercular Agents - pharmacology Bacteria Binding Sites Biology Biosynthesis Chemistry Chemotherapy Conversion Dehydrogenase Dehydrogenases Drug resistance Drug therapy E coli Enzyme Inhibitors - pharmacology Enzymes Health aspects Humans IMP Dehydrogenase - antagonists & inhibitors IMP Dehydrogenase - genetics IMP Dehydrogenase - isolation & purification Inhibitors Inosine monophosphate Kinases Kinetics Ligands Medical screening Medicine Mice Mice, Inbred C57BL Mice, Knockout Microbial Sensitivity Tests Minimum inhibitory concentration Models, Molecular Multidrug resistance Mycobacterium smegmatis Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics NAD Nicotinamide Nicotinamide adenine dinucleotide Permeability Protein Binding Purines R&D Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - genetics Recombinant Proteins - isolation & purification Research & development Scaffolds Small Molecule Libraries - pharmacology Substrate Specificity Target recognition Tuberculosis Tuberculosis - drug therapy
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