Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways

Prostate cancer is one of the leading causes of cancer death among men worldwide. In this study, using transgenic adenocarcinoma of mouse prostate (TRAMP) mice, the effect of diet enriched with 1% w/w ursolic acid (UA) was investigated to evaluate the stage specific chemopreventive activity against...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32476
Hauptverfasser:	Shanmugam, Muthu K, Ong, Tina H, Kumar, Alan Prem, Lun, Chang K, Ho, Paul C, Wong, Peter T H, Hui, Kam M, Sethi, Gautam
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adenocarcinoma Adenocarcinoma - prevention & control Age AKT protein Analysis Angiogenesis Animal tissues Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Biology Blotting, Western Body weight Cancer Cancer prevention Cancer research Cancer treatment Caspase Caspase 3 - metabolism Caspase-3 Chromatography Cyclin D1 Cyclin D1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytotoxicity Diet DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Fruits Gastrointestinal tract Gene Expression Regulation, Neoplastic - drug effects Genetic engineering Health aspects Immunohistochemistry Inflammation Interleukin 6 Kaplan-Meier Estimate Male Mass spectrometry Medical research Medicine Metastasis Mice Mice, Transgenic NF-κB protein Pharmacology Pharmacy Phosphorylation Plasma Polyphenols Prostate cancer Prostatic Neoplasms - prevention & control Scientific imaging Serum levels Signal Transduction - drug effects Spectrophotometry Stat3 protein Studies Survival Survival Analysis Transgenic animals Triterpenes - administration & dosage Triterpenes - pharmacology Tumor necrosis factor-α Ursolic Acid Weight reduction
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