Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions

The fungus C. albicans uses adhesins to interact with human epithelial surfaces in the processes of colonization and pathogenesis. The C. albicans ALS (agglutinin-like sequence) gene family encodes eight large cell-surface glycoproteins (Als1-Als7 and Als9) that have adhesive function. This study ut...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33362-e33362
Hauptverfasser:	Murciano, Celia, Moyes, David L, Runglall, Manohursingh, Tobouti, Priscila, Islam, Ayesha, Hoyer, Lois L, Naglik, Julian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins Adhesion Amino acids Analysis Antigens Biology Blotting, Western c-Fos protein Candida albicans Cell adhesion Cell Adhesion Molecules - metabolism Cell interactions Cell surface Colonization Cytokines Cytokines - metabolism Damage Dual Specificity Phosphatase 1 - metabolism Epithelial cells Epithelial Cells - metabolism Experiments Fos protein Fungal Proteins - genetics Fungal Proteins - metabolism Fungi Glycoproteins Humans Hyphae Immunology Infections Kinases MAP kinase MAP kinase phosphatase Mouth Mucosa - cytology Mouth Mucosa - microbiology Mouth Mucosa - pathology Mucosa Mutants Pathogenesis Phosphorylation Proteins Proto-Oncogene Proteins c-fos - metabolism Signal transduction Signal Transduction - genetics Signaling Yeast
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