Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation

MiRNAs can regulate gene expression through versatile mechanisms that result in increased or decreased expression of the targeted mRNA and it could effect the expression of thousands of protein in a particular cell. An increasing body of evidence suggest that miRNAs action can be modulated by protei...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33144-e33144
Hauptverfasser:	Engels, Bart, Jannot, Guillaume, Remenyi, Judit, Simard, Martin J, Hutvagner, György
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Affinity Animals Argonaute 2 protein Argonaute Proteins - metabolism Base Sequence Binding Binding sites Biology Caenorhabditis elegans Cancer Chromatography, Affinity DNA repair Enzymes Gene expression Gene Expression Regulation - genetics Gene Knockdown Techniques Gene regulation Genes Genetic regulation Genomes HeLa Cells Humans Hypoxia Life sciences Mammals Medical research Messenger RNA MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Sequence Data Polypyrimidine Tract-Binding Protein - genetics Polypyrimidine Tract-Binding Protein - metabolism Protein binding Protein purification Proteins Purification Ribonucleic acid RNA Target recognition
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