Identification of the first functional toxin-antitoxin system in Streptomyces

Toxin-antitoxin (TA) systems are widespread among the plasmids and genomes of bacteria and archaea. This work reports the first description of a functional TA system in Streptomyces that is identical in two species routinely used in the laboratory: Streptomyces lividans and S. coelicolor. The descri...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32977
Hauptverfasser:	Sevillano, Laura, Díaz, Margarita, Yamaguchi, Yoshihiro, Inouye, Masayori, Santamaría, Ramón I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antitoxins Antitoxins - chemistry Antitoxins - metabolism Archaea Bacteria Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - metabolism Bacterial Toxins - chemistry Bacterial Toxins - metabolism Biochemistry Biocompatibility Biofilms Biological products Biology Biosynthesis Cloning Codons Deoxyribonucleic acid DNA DNA, Intergenic - genetics E coli Electrophoretic Mobility Shift Assay Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Gene expression Gene Expression Regulation, Bacterial Genes, Bacterial - genetics Genomes Genomics Medicine Messenger RNA Microbial Viability - genetics Molecular Sequence Data mRNA Operon - genetics Plasmids Promoter Regions, Genetic - genetics Promoters Protein Binding Protein Biosynthesis Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Similarity Streptomyces Streptomyces lividans Streptomyces lividans - cytology Streptomyces lividans - genetics Streptomyces lividans - metabolism Toxicity Toxins Toxins and antitoxins Translation (Genetics) Translation initiation Vectors (Biology)
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