Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex

Nitrotyrosination of proteins, a hallmark of inflammation, may result in the production of MHC-restricted neoantigens that can be recognized by T cells and bypass the constraints of immunological self-tolerance. Here we biochemically and structurally assessed how nitrotyrosination of the lymphocytic...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32805-e32805
Hauptverfasser:	Madhurantakam, Chaithanya, Duru, Adil D, Sandalova, Tatyana, Webb, John R, Achour, Adnane
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimers disease Amino Acids - metabolism Animals Antigenic determinants Antigens Biochemistry Biology Catalysis Cell recognition Comparative analysis Conformation Crystal structure Crystallography, X-Ray Data collection Epitopes H-2 Antigens - chemistry H-2 Antigens - immunology Histocompatibility antigen H-2 Hospitals Hydrogen Hydrogen bonding Hydrogen bonds Immunological tolerance Immunology Inflammation Inflammation - immunology Lymphocytes Lymphocytes T Lymphocytic choriomeningitis virus Lymphocytic choriomeningitis virus - immunology Major histocompatibility complex Major Histocompatibility Complex - immunology Medicine Mice Models, Molecular Neoantigens Nitric oxide Packing Peptides Peptides - chemistry Peptides - metabolism Protein Conformation Protein folding Protein Stability Proteins Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - immunology Recognition Self Structural analysis Structural stability Surface stability T cell receptors T cells T-cell receptor Tyrosine - analogs & derivatives Tyrosine - immunology Viral Proteins - chemistry Viral Proteins - immunology Viruses
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