Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens
Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope...
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| Veröffentlicht in: | PloS one 2012-03, Vol.7 (3), p.e31753-e31753 |
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| description | Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-γ ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002-2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-γ responses among 5-9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30-0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5-9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-γ response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-γ responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology. |
| doi_str_mv | 10.1371/journal.pone.0031753 |
| format | Article |
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Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-γ ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002-2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-γ responses among 5-9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30-0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5-9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-γ response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-γ responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0031753</identifier><identifier>PMID: 22427806</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesives ; Adolescent ; Age groups ; Analysis ; Antigens ; Biology ; Burkitt Lymphoma - epidemiology ; Burkitt Lymphoma - immunology ; Burkitt Lymphoma - parasitology ; Burkitt Lymphoma - virology ; Burkitt's lymphoma ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Child ; Child, Preschool ; Children ; Coinfection - immunology ; Confidence intervals ; Cytokines ; Data analysis ; Development and progression ; Diseases ; Enzyme-linked immunosorbent assay ; Enzyme-Linked Immunospot Assay ; Epidemiology ; Epitopes ; Epstein-Barr virus ; Etiology ; Exposure ; Global health ; Health care ; Herpesvirus 4, Human - immunology ; HIV ; Human immunodeficiency virus ; Humans ; Immunity ; Immunity, Cellular - immunology ; Immunology ; Infant ; Infections ; Interferon ; Interferon-gamma - immunology ; Kenya - epidemiology ; Liver ; Lymphocytes T ; Lymphoma ; Lymphomas ; Malaria ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Medical research ; Medicine ; Pediatrics ; Peptides ; Plasmodium falciparum ; Prevalence ; Proteins ; Public health ; Recurrence ; Surveys ; T cells ; Vaccines ; Vector-borne diseases ; Viruses ; γ-Interferon</subject><ispartof>PloS one, 2012-03, Vol.7 (3), p.e31753-e31753</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Snider et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Snider et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6393-efce1329fb017c477118ecad37cc4c5a231dfb2b80ccbe487490f4d9632173953</citedby><cites>FETCH-LOGICAL-c6393-efce1329fb017c477118ecad37cc4c5a231dfb2b80ccbe487490f4d9632173953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299627/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299627/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22427806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Masucci, Maria G.</contributor><creatorcontrib>Snider, Cynthia J</creatorcontrib><creatorcontrib>Cole, Stephen R</creatorcontrib><creatorcontrib>Chelimo, Kiprotich</creatorcontrib><creatorcontrib>Sumba, Peter Odada</creatorcontrib><creatorcontrib>Macdonald, Pia D M</creatorcontrib><creatorcontrib>John, Chandy C</creatorcontrib><creatorcontrib>Meshnick, Steven R</creatorcontrib><creatorcontrib>Moormann, Ann M</creatorcontrib><title>Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-γ ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002-2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-γ responses among 5-9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30-0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5-9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-γ response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-γ responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology.</description><subject>Adhesives</subject><subject>Adolescent</subject><subject>Age groups</subject><subject>Analysis</subject><subject>Antigens</subject><subject>Biology</subject><subject>Burkitt Lymphoma - epidemiology</subject><subject>Burkitt Lymphoma - immunology</subject><subject>Burkitt Lymphoma - parasitology</subject><subject>Burkitt Lymphoma - virology</subject><subject>Burkitt's lymphoma</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Coinfection - immunology</subject><subject>Confidence intervals</subject><subject>Cytokines</subject><subject>Data analysis</subject><subject>Development and progression</subject><subject>Diseases</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzyme-Linked Immunospot Assay</subject><subject>Epidemiology</subject><subject>Epitopes</subject><subject>Epstein-Barr virus</subject><subject>Etiology</subject><subject>Exposure</subject><subject>Global health</subject><subject>Health care</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunity, Cellular - immunology</subject><subject>Immunology</subject><subject>Infant</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interferon-gamma - immunology</subject><subject>Kenya - epidemiology</subject><subject>Liver</subject><subject>Lymphocytes T</subject><subject>Lymphoma</subject><subject>Lymphomas</subject><subject>Malaria</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Pediatrics</subject><subject>Peptides</subject><subject>Plasmodium falciparum</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Public health</subject><subject>Recurrence</subject><subject>Surveys</subject><subject>T cells</subject><subject>Vaccines</subject><subject>Vector-borne 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titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snider, Cynthia J</au><au>Cole, Stephen R</au><au>Chelimo, Kiprotich</au><au>Sumba, Peter Odada</au><au>Macdonald, Pia D M</au><au>John, Chandy C</au><au>Meshnick, Steven R</au><au>Moormann, Ann M</au><au>Masucci, Maria G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-03-12</date><risdate>2012</risdate><volume>7</volume><issue>3</issue><spage>e31753</spage><epage>e31753</epage><pages>e31753-e31753</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Plasmodium falciparum malaria (Pf-malaria) and Epstein Barr Virus (EBV) infections coexist in children at risk for endemic Burkitt's lymphoma (eBL); yet studies have only glimpsed the cumulative effect of Pf-malaria on EBV-specific immunity. Using pooled EBV lytic and latent CD8+ T-cell epitope-peptides, IFN-γ ELISPOT responses were surveyed three times among children (10 months to 15 years) in Kenya from 2002-2004. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated in association with Pf-malaria exposure, defined at the district-level (Kisumu: holoendemic; Nandi: hypoendemic) and the individual-level. We observed a 46% decrease in positive EBV lytic antigen IFN-γ responses among 5-9 year olds residing in Kisumu compared to Nandi (PR: 0.54; 95% CI: 0.30-0.99). Individual-level analysis in Kisumu revealed further impairment of EBV lytic antigen responses among 5-9 year olds consistently infected with Pf-malaria compared to those never infected. There were no observed district- or individual-level differences between Pf-malaria exposure and EBV latent antigen IFN-γ response. The gradual decrease of EBV lytic antigen but not latent antigen IFN-γ responses after primary infection suggests a specific loss in immunological control over the lytic cycle in children residing in malaria holoendemic areas, further refining our understanding of eBL etiology.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22427806</pmid><doi>10.1371/journal.pone.0031753</doi><tpages>e31753</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-03, Vol.7 (3), p.e31753-e31753 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1323990510 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adhesives Adolescent Age groups Analysis Antigens Biology Burkitt Lymphoma - epidemiology Burkitt Lymphoma - immunology Burkitt Lymphoma - parasitology Burkitt Lymphoma - virology Burkitt's lymphoma CD8 antigen CD8-Positive T-Lymphocytes - immunology Child Child, Preschool Children Coinfection - immunology Confidence intervals Cytokines Data analysis Development and progression Diseases Enzyme-linked immunosorbent assay Enzyme-Linked Immunospot Assay Epidemiology Epitopes Epstein-Barr virus Etiology Exposure Global health Health care Herpesvirus 4, Human - immunology HIV Human immunodeficiency virus Humans Immunity Immunity, Cellular - immunology Immunology Infant Infections Interferon Interferon-gamma - immunology Kenya - epidemiology Liver Lymphocytes T Lymphoma Lymphomas Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Medical research Medicine Pediatrics Peptides Plasmodium falciparum Prevalence Proteins Public health Recurrence Surveys T cells Vaccines Vector-borne diseases Viruses γ-Interferon |
| title | Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T22%3A21%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recurrent%20Plasmodium%20falciparum%20malaria%20infections%20in%20Kenyan%20children%20diminish%20T-cell%20immunity%20to%20Epstein%20Barr%20virus%20lytic%20but%20not%20latent%20antigens&rft.jtitle=PloS%20one&rft.au=Snider,%20Cynthia%20J&rft.date=2012-03-12&rft.volume=7&rft.issue=3&rft.spage=e31753&rft.epage=e31753&rft.pages=e31753-e31753&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0031753&rft_dat=%3Cgale_plos_%3EA477133759%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1323990510&rft_id=info:pmid/22427806&rft_galeid=A477133759&rft_doaj_id=oai_doaj_org_article_df7339e97d224d37bc0a40969adf3b5e&rfr_iscdi=true |