Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats

The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling in VAN via an early growth response 1 (EGR1) dependent pathway thereby increasing their sensitiv...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32967-e32967
Hauptverfasser:	de Lartigue, Guillaume, Barbier de la Serre, Claire, Espero, Elvis, Lee, Jennifer, Raybould, Helen E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Anatomy & physiology Animals Biology Body Weight Cannabinoid CB1 receptors Cells, Cultured Cholecystokinin Cholecystokinin - metabolism Cholecystokinin - pharmacology Cocaine Diet Diet, High-Fat Down-regulation Eating EGR-1 protein Food Food intake Genotype & phenotype High fat diet Hyperphagia Ingestion Insulin resistance Leptin Leptin - metabolism Leptin - pharmacology Male Medicine Melanin Melanin-concentrating hormone Neurons Neurons, Afferent - drug effects Neurons, Afferent - metabolism Neuropeptides Obesity Obesity - etiology Peptides Phenotype Physiology Rats Rats, Sprague-Dawley Rats, Zucker Receptors Rodents Satiation - drug effects Satiety Sensitivity Sensory neurons Signal Transduction - drug effects Signaling Vagus nerve Vagus Nerve - drug effects Vagus Nerve - metabolism Veterinary colleges Veterinary medicine
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