Foxp2 mutations impair auditory-motor association learning

Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-described examples of monogenic speech and language disorders. Acquisition of proficient spoken language involves auditory-guided vocal learning, a specialized form of sensory-motor association learning. The impact of...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33130-e33130
Hauptverfasser:	Kurt, Simone, Fisher, Simon E, Ehret, Günter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animal models Animals Association Learning Associative learning Auditory discrimination learning Auditory pathways Biology Cerebellum Conditioning Cortex (auditory) Cortex (somatosensory) Deoxyribonucleic acid Disorders DNA Etiology False alarms Female Forkhead Transcription Factors - genetics Foxp2 protein Human motion Language Language disorders Learning Mammals Medicine Mice Mice, Inbred C3H Mice, Knockout Missense mutation Motor ability Motor skill Motor skill learning Motor Skills Mus musculus Mutation Neostriatum Neurobiology Neurosciences Nonsense mutation Psychomotor Performance Repressor Proteins - genetics Rodents Sensorimotor integration Skills Social and Behavioral Sciences Somatosensory cortex Sound Speech Vocalization behavior
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