Medication adherence in type 2 diabetes: the ENTRED study 2007, a French Population-Based Study
Adherence to prescribed medications is a key dimension of healthcare quality. The aim of this large population-based study was to evaluate self-reported medication adherence and to identify factors linked with poor adherence in patients with type 2 diabetes in France. The ENTRED study 2007, a French...
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| Veröffentlicht in: | PloS one 2012-03, Vol.7 (3), p.e32412-e32412 |
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| description | Adherence to prescribed medications is a key dimension of healthcare quality. The aim of this large population-based study was to evaluate self-reported medication adherence and to identify factors linked with poor adherence in patients with type 2 diabetes in France.
The ENTRED study 2007, a French national survey of people treated for diabetes, was based on a representative sample of patients who claimed reimbursement for oral hypoglycaemic agents and/or insulin at least three times between August 2006 and July 2007, and who were randomly selected from the database of the two main National Health Insurance Systems. Medication adherence was determined using a six-item self-administered questionnaire. A multinomial polychotomous logistic regression model was used to identify factors associated with medication adherence in the 3,637 persons with type 2 diabetes.
Thirty nine percent of patients reported good medication adherence, 49% medium adherence and 12% poor adherence. The factors significantly associated with poor adherence in multivariate analysis were socio-demographic factors: age 8% and existing diabetes complications; and health care-related factors: difficulties for taking medication alone, decision making by the patient only, poor acceptability of medical recommendations, lack of family or social support, need for information on treatment, reporting no confidence in the future, need for medical support and follow-up by a specialist physician.
In a country with a high level of access to healthcare, our study demonstrated a substantial low level of medication adherence in type 2 diabetic patients. Better identification of those with poor adherence and individualised suitable recommendations remain essential for better healthcare management. |
| doi_str_mv | 10.1371/journal.pone.0032412 |
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The ENTRED study 2007, a French national survey of people treated for diabetes, was based on a representative sample of patients who claimed reimbursement for oral hypoglycaemic agents and/or insulin at least three times between August 2006 and July 2007, and who were randomly selected from the database of the two main National Health Insurance Systems. Medication adherence was determined using a six-item self-administered questionnaire. A multinomial polychotomous logistic regression model was used to identify factors associated with medication adherence in the 3,637 persons with type 2 diabetes.
Thirty nine percent of patients reported good medication adherence, 49% medium adherence and 12% poor adherence. The factors significantly associated with poor adherence in multivariate analysis were socio-demographic factors: age <45 years, non-European geographical origin, financial difficulties and being professionally active; disease and therapy-related factors: HbA(1c)>8% and existing diabetes complications; and health care-related factors: difficulties for taking medication alone, decision making by the patient only, poor acceptability of medical recommendations, lack of family or social support, need for information on treatment, reporting no confidence in the future, need for medical support and follow-up by a specialist physician.
In a country with a high level of access to healthcare, our study demonstrated a substantial low level of medication adherence in type 2 diabetic patients. Better identification of those with poor adherence and individualised suitable recommendations remain essential for better healthcare management.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0032412</identifier><identifier>PMID: 22403654</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesion ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Complications ; Decision making ; Demographics ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetics ; Drug therapy ; Drugs ; Education ; Female ; France ; Health care ; Health insurance ; Health surveys ; Hospitals ; Humans ; Hypertension ; Insulin ; Life Sciences ; Low level ; Male ; Medical care quality ; Medical research ; Medication adherence ; Medication Adherence - statistics & numerical data ; Medicine ; Metabolism ; Middle Aged ; Mortality ; Multivariate Analysis ; National health insurance ; Patient compliance ; Patients ; Population studies ; Population-based studies ; Questionnaires ; Regression analysis ; Regression models ; Response rates ; Risk Factors ; Santé publique et épidémiologie ; Self Report ; Skill development ; Social aspects ; Social interactions ; Studies ; Substance abuse treatment ; Surveys ; Type 2 diabetes ; Young Adult</subject><ispartof>PloS one, 2012-03, Vol.7 (3), p.e32412-e32412</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Tiv et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Tiv et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-c059738a713056fc49f4b4a5018fa3c6b68f00d15dbefb4e012241dddd655aed3</citedby><cites>FETCH-LOGICAL-c791t-c059738a713056fc49f4b4a5018fa3c6b68f00d15dbefb4e012241dddd655aed3</cites><orcidid>0000-0002-6716-7468</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293796/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293796/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22403654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00823393$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tiv, Michel</creatorcontrib><creatorcontrib>Viel, Jean-François</creatorcontrib><creatorcontrib>Mauny, Frédéric</creatorcontrib><creatorcontrib>Eschwège, Eveline</creatorcontrib><creatorcontrib>Weill, Alain</creatorcontrib><creatorcontrib>Fournier, Cécile</creatorcontrib><creatorcontrib>Fagot-Campagna, Anne</creatorcontrib><creatorcontrib>Penfornis, Alfred</creatorcontrib><title>Medication adherence in type 2 diabetes: the ENTRED study 2007, a French Population-Based Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Adherence to prescribed medications is a key dimension of healthcare quality. The aim of this large population-based study was to evaluate self-reported medication adherence and to identify factors linked with poor adherence in patients with type 2 diabetes in France.
The ENTRED study 2007, a French national survey of people treated for diabetes, was based on a representative sample of patients who claimed reimbursement for oral hypoglycaemic agents and/or insulin at least three times between August 2006 and July 2007, and who were randomly selected from the database of the two main National Health Insurance Systems. Medication adherence was determined using a six-item self-administered questionnaire. A multinomial polychotomous logistic regression model was used to identify factors associated with medication adherence in the 3,637 persons with type 2 diabetes.
Thirty nine percent of patients reported good medication adherence, 49% medium adherence and 12% poor adherence. The factors significantly associated with poor adherence in multivariate analysis were socio-demographic factors: age <45 years, non-European geographical origin, financial difficulties and being professionally active; disease and therapy-related factors: HbA(1c)>8% and existing diabetes complications; and health care-related factors: difficulties for taking medication alone, decision making by the patient only, poor acceptability of medical recommendations, lack of family or social support, need for information on treatment, reporting no confidence in the future, need for medical support and follow-up by a specialist physician.
In a country with a high level of access to healthcare, our study demonstrated a substantial low level of medication adherence in type 2 diabetic patients. 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statistics & numerical data</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>National health insurance</subject><subject>Patient compliance</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Response rates</subject><subject>Risk Factors</subject><subject>Santé publique et épidémiologie</subject><subject>Self Report</subject><subject>Skill development</subject><subject>Social aspects</subject><subject>Social interactions</subject><subject>Studies</subject><subject>Substance abuse treatment</subject><subject>Surveys</subject><subject>Type 2 diabetes</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYmgSaRIs_YrvmAqmMjlUqDG2DW8uxT5pUaVziZKL_HmftpnbaBfaFrePnfW0f-yTJa4KHhEnyceG7pjbVcOVrGGLMaErok-SQKEYHgmL2dGd-kLwIYYExZyMhnicHlKaYCZ4eJvo7uNKatvQ1Mq6ABmoLqKxRu14BosiVJoMWwifUFoAmP64vJ19RaDu3RhRj-QEZdNZrCvTTr7rq1mjwxQRw6KqnXibPclMFeLUdj5JfZ5Pr0_PB7OLb9HQ8G1ipSDuwmCvJRkYShrnIbaryNEsNx2SUG2ZFJkY5xo5wl0GepYBJvAJxsQnODTh2lLzd-K4qH_Q2N0ETRpkSKec8EtMN4bxZ6FVTLk2z1t6U-jbgm7k2TVvaCrQAark1qZWZSZ1QJmdKYUOFY0RKx6LX5-1uXbYEZ6FuG1Ptme6v1GWh5_5GM6qYVCIanGwMigey8_FM9zGMR5QxxW5IZN9vN2v8nw5Cq5dlsFBVpgbfBa2oFIoy3LsePyAfT8SWmpt417LOfTyi7T31OJWScEmxitTwESp2B8vSxj-XlzG-JzjZE0Smhb_t3HQh6OnV5f-zF7_32Xc7bAGmaovgq67_aWEfTDegbXwIDeT3iSVY9yVzlw3dl4zelkyUvdl9y3vRXY2wf_TrDZ8</recordid><startdate>20120305</startdate><enddate>20120305</enddate><creator>Tiv, Michel</creator><creator>Viel, Jean-François</creator><creator>Mauny, Frédéric</creator><creator>Eschwège, Eveline</creator><creator>Weill, Alain</creator><creator>Fournier, Cécile</creator><creator>Fagot-Campagna, Anne</creator><creator>Penfornis, Alfred</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6716-7468</orcidid></search><sort><creationdate>20120305</creationdate><title>Medication adherence in type 2 diabetes: the ENTRED study 2007, a French Population-Based Study</title><author>Tiv, Michel ; Viel, Jean-François ; Mauny, Frédéric ; Eschwège, Eveline ; Weill, Alain ; Fournier, Cécile ; Fagot-Campagna, Anne ; Penfornis, Alfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c791t-c059738a713056fc49f4b4a5018fa3c6b68f00d15dbefb4e012241dddd655aed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adhesion</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Complications</topic><topic>Decision making</topic><topic>Demographics</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tiv, Michel</au><au>Viel, Jean-François</au><au>Mauny, Frédéric</au><au>Eschwège, Eveline</au><au>Weill, Alain</au><au>Fournier, Cécile</au><au>Fagot-Campagna, Anne</au><au>Penfornis, Alfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medication adherence in type 2 diabetes: the ENTRED study 2007, a French Population-Based Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-03-05</date><risdate>2012</risdate><volume>7</volume><issue>3</issue><spage>e32412</spage><epage>e32412</epage><pages>e32412-e32412</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Adherence to prescribed medications is a key dimension of healthcare quality. The aim of this large population-based study was to evaluate self-reported medication adherence and to identify factors linked with poor adherence in patients with type 2 diabetes in France.
The ENTRED study 2007, a French national survey of people treated for diabetes, was based on a representative sample of patients who claimed reimbursement for oral hypoglycaemic agents and/or insulin at least three times between August 2006 and July 2007, and who were randomly selected from the database of the two main National Health Insurance Systems. Medication adherence was determined using a six-item self-administered questionnaire. A multinomial polychotomous logistic regression model was used to identify factors associated with medication adherence in the 3,637 persons with type 2 diabetes.
Thirty nine percent of patients reported good medication adherence, 49% medium adherence and 12% poor adherence. The factors significantly associated with poor adherence in multivariate analysis were socio-demographic factors: age <45 years, non-European geographical origin, financial difficulties and being professionally active; disease and therapy-related factors: HbA(1c)>8% and existing diabetes complications; and health care-related factors: difficulties for taking medication alone, decision making by the patient only, poor acceptability of medical recommendations, lack of family or social support, need for information on treatment, reporting no confidence in the future, need for medical support and follow-up by a specialist physician.
In a country with a high level of access to healthcare, our study demonstrated a substantial low level of medication adherence in type 2 diabetic patients. Better identification of those with poor adherence and individualised suitable recommendations remain essential for better healthcare management.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22403654</pmid><doi>10.1371/journal.pone.0032412</doi><tpages>e32412</tpages><orcidid>https://orcid.org/0000-0002-6716-7468</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-03, Vol.7 (3), p.e32412-e32412 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1323964555 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adhesion Adolescent Adult Aged Aged, 80 and over Analysis Complications Decision making Demographics Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetics Drug therapy Drugs Education Female France Health care Health insurance Health surveys Hospitals Humans Hypertension Insulin Life Sciences Low level Male Medical care quality Medical research Medication adherence Medication Adherence - statistics & numerical data Medicine Metabolism Middle Aged Mortality Multivariate Analysis National health insurance Patient compliance Patients Population studies Population-based studies Questionnaires Regression analysis Regression models Response rates Risk Factors Santé publique et épidémiologie Self Report Skill development Social aspects Social interactions Studies Substance abuse treatment Surveys Type 2 diabetes Young Adult |
| title | Medication adherence in type 2 diabetes: the ENTRED study 2007, a French Population-Based Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T08%3A14%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Medication%20adherence%20in%20type%202%20diabetes:%20the%20ENTRED%20study%202007,%20a%20French%20Population-Based%20Study&rft.jtitle=PloS%20one&rft.au=Tiv,%20Michel&rft.date=2012-03-05&rft.volume=7&rft.issue=3&rft.spage=e32412&rft.epage=e32412&rft.pages=e32412-e32412&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0032412&rft_dat=%3Cgale_plos_%3EA477157209%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1323964555&rft_id=info:pmid/22403654&rft_galeid=A477157209&rft_doaj_id=oai_doaj_org_article_6e2c5ca4c7ba4d69af3990a26d3177d3&rfr_iscdi=true |