Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein

A new homozygous humanized transgenic mouse strain, HLA-A2.1(+/+)HLA-DP4(+/+) hCD4(+/+)mCD4(-/-)IAβ(-/-)β2m(-/-) (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2(+/+)β2m(-/-) (A2) mouse and our previously created HLA-DP4(+/+) hCD4(+/+)mCD4(-/-)IAβ(-/-) (DP4) mouse. We confi...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32247-e32247
Hauptverfasser:	Ru, Zhitao, Xiao, Wenjun, Pajot, Anthony, Kou, Zhihua, Sun, Shihui, Maillere, Bernard, Zhao, Guangyu, Ojcius, David M, Lone, Yu-Chun, Zhou, Yusen
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Analysis Animal models Animals Antibodies Antibodies, Monoclonal, Humanized - genetics Antibodies, Monoclonal, Humanized - immunology Antigenic determinants B cells Biology Biomarkers - metabolism CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Deoxyribonucleic acid DNA DNA vaccines Envelope protein Epitope Mapping - methods Epitopes Genetic engineering Health aspects Hepatitis Hepatitis B Hepatitis B surface antigen Hepatitis B Surface Antigens - immunology Hepatitis B virus Hepatitis B virus - immunology Histocompatibility antigen HLA HLA antigens HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology HLA-DP beta-Chains - genetics HLA-DP beta-Chains - immunology Homozygote Human behavior Human populations Humans Immunity, Humoral - immunology Immunization Infection Lymphocytes Medicine Mice Mice, Transgenic Phenotype Population genetics Protein A Rodents T cell receptors Transgenes Transgenic mice Vaccination Vaccine development Vaccines Vaccines, DNA - immunology Viral envelope proteins Viral Envelope Proteins - immunology Viral Vaccines - immunology Viruses
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