Absence of association between N-acetyltransferase 2 acetylator status and colorectal cancer susceptibility: based on evidence from 40 studies

N-Acetyltransferase (NAT) 2 is an important enzyme involved in the metabolism of different xenobiotics, including potential carcinogens, whose phenotypes were reported to be related to individual susceptibility to colorectal cancer (CRC). However, the results remain conflicting. To assess the relati...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32425
Hauptverfasser:	Zhang, Lou qian, Zhou, Jian nong, Wang, Jun, Liang, Guo dong, Li, Jing ying, Zhu, Yi dan, Su, Yun tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferase Analysis Arylamine N-Acetyltransferase - metabolism Biology Biomarkers Bladder cancer Blood groups Breast cancer Cancer Cancer research Carcinogens Chemotherapy Clinical trials Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Confidence intervals Development and progression Disease Susceptibility Enzymes Ethnicity Female Gastric cancer Gastroenterology Genes Genotyping Geriatrics Haplotypes Health risk assessment Heterogeneity Humans Literature searches Localization Lung cancer Male Meat Medical ethics Medicine Meta-analysis Metabolism N-Acetyltransferase 2 Phenotype Physiological aspects Publication Bias Risk Smoking Stomach cancer Studies Xenobiotics
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