DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells

The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability. Genomic instability is most often linked to DNA repair deficiencies, which indicates that scree...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e30541
Hauptverfasser:	Luo, Li Z, Gopalakrishna-Pillai, Sailesh, Nay, Stephanie L, Park, Sang-Won, Bates, Steven E, Zeng, Xianmin, Iverson, Linda E, O'Connor, Timothy R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Alkylating Agents - pharmacology Alkylation Annealing Apoptosis Apoptosis - radiation effects Biology Biotechnology Cancer Cell Line Cell lines Chromosomes Comparative analysis Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - radiation effects DNA methylation DNA Repair Embryo cells Embryonic stem cells Embryos Fibroblasts Fibroblasts - metabolism Fibroblasts - radiation effects Fluxes Gene expression Genomes Genomic instability Humans Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Instability Karyotypes Light effects Medical research Medical treatment Melanoma Microsatellite Instability Mutation Nucleotide excision repair Pluripotency Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - radiation effects Pyrimidine Dimers - radiation effects Radiation (Physics) Reactive Oxygen Species - metabolism Repair Rodents Screening Senescence Stability Stem cell research Stem cells Sulfuric Acid Esters - pharmacology Transcription, Genetic - radiation effects U.V. radiation Ultraviolet radiation Ultraviolet Rays - adverse effects
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