ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is expressed during embryogenesis and by certain leukemias, but not by normal adult tissues. Here we show that the neoplastic cells of many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e31127-e31127
Hauptverfasser:	Zhang, Suping, Chen, Liguang, Cui, Bing, Chuang, Han-Yu, Yu, Jianqiang, Wang-Rodriguez, Jessica, Tang, Li, Chen, George, Basak, Grzegorz W, Kipps, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenosine AKT protein Animal tissues Animals Antibodies, Monoclonal - immunology Antibody Specificity Apoptosis Biology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Casein Casein kinase I Cell growth Cell Proliferation Cell Survival CHO Cells Cloning Cricetinae Cricetulus Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Dwarfism Embryogenesis Embryonic growth stage Enzyme Activation Female Gene Expression Regulation, Neoplastic Genomes Growth Growth factors Health aspects Histograms Humans Kinases Leukemia Medicine Mice Middle Aged Mutation Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein binding Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism Receptor Tyrosine Kinase-like Orphan Receptors - genetics Receptor Tyrosine Kinase-like Orphan Receptors - immunology Receptor Tyrosine Kinase-like Orphan Receptors - metabolism Signal Transduction Signaling Transcription factors Tumor cell lines Tyrosine Wnt protein Wnt Proteins - metabolism Wnt-5a Protein
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