iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling

Calcium independent group VIA phospholipase A(2) (iPLA(2)β) is up-regulated in vascular smooth muscle cells in some diseases, but whether the up-regulated iPLA(2)β affects vascular morphology and blood pressure is unknown. The current study addresses this question by evaluating the basal- and angiot...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31850-e31850
Hauptverfasser:	Calderon, Lindsay E, Liu, Shu, Su, Wen, Xie, Zhongwen, Guo, Zhenheng, Eberhard, Wanda, Gong, Ming C
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensin II - administration & dosage Angiotensin II - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiopathology Arachidonate 15-Lipoxygenase Arachidonic Acid - metabolism Arteries Biology Blood Blood pressure Blood Pressure - drug effects c-Jun protein Calcium Cell proliferation Cell Proliferation - drug effects Circulatory system Coronary vessels Diabetes Diastole - drug effects Diastolic pressure Group VI Phospholipases A2 - metabolism Hypertension Hypertension - enzymology Hypertension - pathology Hypertension - physiopathology Hypertrophy Internal medicine Ischemia Kinases Leucine Leucine - metabolism Lipoxygenase Medicine Mesenteric Arteries - drug effects Mesenteric Arteries - physiopathology Metabolites Mice Mice, Inbred C57BL Mice, Transgenic Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - physiopathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Organ Specificity - drug effects p38 Mitogen-Activated Protein Kinases - metabolism Phospholipase Phospholipase A2 Phosphorylation Physiology Proteins Proto-Oncogene Proteins c-jun - metabolism Rats Rodents Signal Transduction - drug effects Smooth muscle Transcription factors Transgenic mice
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