Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication

In bronchopulmonary dysplasia (BPD), alveolar septae are thickened with collagen and α-smooth muscle actin, transforming growth factor (TGF)-β-positive myofibroblasts. Periostin, a secreted extracellular matrix protein, is involved in TGF-β-mediated fibrosis and myofibroblast differentiation. We hyp...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31336
Hauptverfasser:	Bozyk, Paul D, Bentley, J Kelley, Popova, Antonia P, Anyanwu, Anuli C, Linn, Marisa D, Goldsmith, Adam M, Pryhuber, Gloria S, Moore, Bethany B, Hershenson, Marc B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Aged Aged, 80 and over Alveoli Animal diseases Animal models Animals Animals, Newborn Biology Bone morphogenetic proteins Bronchopulmonary Dysplasia - complications Bronchopulmonary Dysplasia - metabolism Bronchopulmonary Dysplasia - pathology Carbon tetrachloride Cell Adhesion Molecules - deficiency Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Differentiation - drug effects Collagen Deoxyribonucleic acid Differentiation DNA DNA - biosynthesis DNA synthesis Dysplasia Elastin Esophagus Exposure Extracellular matrix Female Fibroblasts Fibrosis Gene expression Gene Expression Regulation, Developmental - drug effects Gene Knockout Techniques Genetic engineering Growth factors Humans Hyperoxia Hyperoxia - complications Hyperoxia - genetics Hyperoxia - pathology Hyperoxia - prevention & control Hypoventilation - complications Hypoventilation - metabolism Hypoventilation - pathology Immunology Infant, Newborn Infants Internal medicine Ligands Lungs Male Matrix protein Medical schools Medicine Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchyme Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Morphogenesis Myofibroblasts - drug effects Myofibroblasts - metabolism Myofibroblasts - pathology Neonates Newborn babies Newborn infants Oxygen Pediatrics Phenotype Physiology Proteins Pulmonary Alveoli - drug effects Pulmonary Alveoli - growth & development Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary arteries RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Smooth muscle Stem cells Stromal cells Synthesis Thickening Transforming growth factor Transforming Growth Factor beta - pharmacology Transforming growth factors
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