Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay

5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid. Here, we investigated the regulation of 5-LO mRNA expression by alternative splicing and nonsense-mediated mRNA decay (NMD). In the p...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31363
Hauptverfasser:	Ochs, Meike J, Sorg, Bernd L, Pufahl, Laura, Grez, Manuel, Suess, Beatrix, Steinhilber, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Alternative splicing Alternative Splicing - drug effects Alternative Splicing - genetics Arachidonate 5-lipoxygenase Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Arachidonic acid Biology Biosynthesis Blotting, Western Brain cancer Calcitriol - pharmacology Cell differentiation Cell Differentiation - drug effects Cell Line Codons Decay Deoxyribonucleic acid Differentiation (biology) DNA Gene expression Gene Expression Regulation, Enzymologic - drug effects Gene Knockdown Techniques Gene regulation Genes Genetic aspects Growth factors Humans Inflammation Leukotrienes Lipoxygenase Medicine Messenger RNA Monocytes mRNA turnover Myogenesis Nonsense Mediated mRNA Decay - drug effects Nonsense Mediated mRNA Decay - genetics Nonsense-mediated mRNA decay Pharmaceuticals Physiological aspects Post-transcription Proteins Puromycin - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Trans-Activators - metabolism Transcription (Genetics) Transcription, Genetic - drug effects Transforming Growth Factor beta1 - pharmacology Tumors
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