Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW
Elevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total...
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| creator | Johannsen, Neil M Swift, Damon L Johnson, William D Dixit, Vishwa D Earnest, Conrad P Blair, Steven N Church, Timothy S |
| description | Elevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total WBC and WBC subfraction counts.
To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-α, C-reactive protein), fasting glucose metabolism, and adiponectin.
Data from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg(-1)⋅week(-1) (KKW) for 6 months at an intensity of 50% VO2peak.
A dose-dependent decrease in total WBC counts (trend P = 0.002) was observed with a significant decrease in the 12KKW group (-163.1±140.0 cells/µL; mean±95%CI) compared with the control (138.6±144.7 cells/µL). A similar response was seen in the neutrophil subfraction (trend P = 0.001) with a significant decrease in the 12KKW group (-152.6±115.1 cells/µL) compared with both the control and 4KKW groups (96.4±119.0 and 21.9±95.3 cells/µL, respectively) and in the 8KKW group (-102.4±125.0 cells/µL) compared with the control. When divided into high/low baseline WBC categories (median split), a dose-dependent decrease in both total WBCs (P = 0.003) and neutrophils (P |
| doi_str_mv | 10.1371/journal.pone.0031319 |
| format | Article |
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To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-α, C-reactive protein), fasting glucose metabolism, and adiponectin.
Data from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg(-1)⋅week(-1) (KKW) for 6 months at an intensity of 50% VO2peak.
A dose-dependent decrease in total WBC counts (trend P = 0.002) was observed with a significant decrease in the 12KKW group (-163.1±140.0 cells/µL; mean±95%CI) compared with the control (138.6±144.7 cells/µL). A similar response was seen in the neutrophil subfraction (trend P = 0.001) with a significant decrease in the 12KKW group (-152.6±115.1 cells/µL) compared with both the control and 4KKW groups (96.4±119.0 and 21.9±95.3 cells/µL, respectively) and in the 8KKW group (-102.4±125.0 cells/µL) compared with the control. When divided into high/low baseline WBC categories (median split), a dose-dependent decrease in both total WBCs (P = 0.003) and neutrophils (P<0.001) was observed in women with high baseline WBC counts. The effects of exercise dose on total WBC and neutrophil counts persisted after accounting for significant independent effects of change in waist circumference and IL-6.
Aerobic exercise training reduces total WBC and neutrophil counts, in a dose-dependent manner, in overweight/obese postmenopausal women and is especially beneficial for those with systemic low grade inflammation.
NCT00011193.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0031319</identifier><identifier>PMID: 22363616</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adiponectin ; Adipose tissue ; Aged ; Analysis ; Anthropometry ; Biomarkers ; Biomedical research ; Blood ; Blood cells ; Body weight ; C-reactive protein ; Cardiovascular disease ; Cardiovascular diseases ; Chronic illnesses ; Clinical trials ; Coronary artery disease ; Coronary heart disease ; Cytokines ; Diabetes ; Disease control ; Disease prevention ; Dosage ; Drug dosages ; Energy expenditure ; Exercise ; Exercise - physiology ; Fasting ; Female ; Fitness ; Fitness equipment ; Glucose ; Glucose - metabolism ; Health care ; Health risks ; Heart ; Heart diseases ; Humans ; Inflammation - pathology ; Insulin resistance ; Interleukin 6 ; Leukocyte Count ; Leukocytes (neutrophilic) ; Medical research ; Medicine ; Metabolism ; Middle Aged ; Monocytes ; Neutrophils - immunology ; Obesity ; Overweight ; Physical Fitness ; Physical training ; Physiological aspects ; Post-menopause ; Postmenopausal women ; Postmenopause - blood ; Postmenopause - immunology ; Preventive medicine ; Protein turnover ; Public health ; Quality ; Statistics, Nonparametric ; Studies ; Subcellular Fractions - metabolism ; Surgeons General ; Tumor necrosis factor ; Tumor necrosis factor-α ; White blood cell count ; Womens health</subject><ispartof>PloS one, 2012-02, Vol.7 (2), p.e31319-e31319</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Johannsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Johannsen et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-b92ab84d090fb13233c09023ecff746eca887e698b58f29ed44d62be075518863</citedby><cites>FETCH-LOGICAL-c592t-b92ab84d090fb13233c09023ecff746eca887e698b58f29ed44d62be075518863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281960/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281960/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22363616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Calbet, Jose A. L.</contributor><creatorcontrib>Johannsen, Neil M</creatorcontrib><creatorcontrib>Swift, Damon L</creatorcontrib><creatorcontrib>Johnson, William D</creatorcontrib><creatorcontrib>Dixit, Vishwa D</creatorcontrib><creatorcontrib>Earnest, Conrad P</creatorcontrib><creatorcontrib>Blair, Steven N</creatorcontrib><creatorcontrib>Church, Timothy S</creatorcontrib><title>Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Elevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total WBC and WBC subfraction counts.
To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-α, C-reactive protein), fasting glucose metabolism, and adiponectin.
Data from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg(-1)⋅week(-1) (KKW) for 6 months at an intensity of 50% VO2peak.
A dose-dependent decrease in total WBC counts (trend P = 0.002) was observed with a significant decrease in the 12KKW group (-163.1±140.0 cells/µL; mean±95%CI) compared with the control (138.6±144.7 cells/µL). A similar response was seen in the neutrophil subfraction (trend P = 0.001) with a significant decrease in the 12KKW group (-152.6±115.1 cells/µL) compared with both the control and 4KKW groups (96.4±119.0 and 21.9±95.3 cells/µL, respectively) and in the 8KKW group (-102.4±125.0 cells/µL) compared with the control. When divided into high/low baseline WBC categories (median split), a dose-dependent decrease in both total WBCs (P = 0.003) and neutrophils (P<0.001) was observed in women with high baseline WBC counts. The effects of exercise dose on total WBC and neutrophil counts persisted after accounting for significant independent effects of change in waist circumference and IL-6.
Aerobic exercise training reduces total WBC and neutrophil counts, in a dose-dependent manner, in overweight/obese postmenopausal women and is especially beneficial for those with systemic low grade inflammation.
NCT00011193.</description><subject>Adiponectin</subject><subject>Adipose tissue</subject><subject>Aged</subject><subject>Analysis</subject><subject>Anthropometry</subject><subject>Biomarkers</subject><subject>Biomedical research</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Body weight</subject><subject>C-reactive protein</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Coronary artery disease</subject><subject>Coronary heart disease</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Dosage</subject><subject>Drug dosages</subject><subject>Energy expenditure</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Fasting</subject><subject>Female</subject><subject>Fitness</subject><subject>Fitness equipment</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Health care</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Insulin resistance</subject><subject>Interleukin 6</subject><subject>Leukocyte Count</subject><subject>Leukocytes (neutrophilic)</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Neutrophils - immunology</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Physical Fitness</subject><subject>Physical training</subject><subject>Physiological aspects</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Postmenopause - blood</subject><subject>Postmenopause - immunology</subject><subject>Preventive medicine</subject><subject>Protein turnover</subject><subject>Public health</subject><subject>Quality</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Subcellular Fractions - metabolism</subject><subject>Surgeons General</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-α</subject><subject>White blood cell count</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUttu1DAQjRCIlsIfILDEA_CwS2wnvvCAVJYFKlVCQqA-WrYz3nqVxFs74fId_DAOm1ZdVOUhk8k5Z2aOTlE8xeUSU47fbMMYe90ud6GHZVlSTLG8VxxjScmCkZLev1UfFY9S2pZlTQVjD4sjQiijDLPj4s_aObADCg41PpcR-gE1IUGaWhpiMN4i-AXR-gQo9GgIg27Rz0s_ADJtCA2y0Lbo1cX71Wuk-wblAqXRuKjt4DOhHzsDEfke7UIaOujDTo9p0gj54y2KkMZ2SMjF0KEPX9cXj4sHTrcJnszvk-L7x_W31efF-ZdPZ6vT84WtJRkWRhJtRNWUsnQGU0KpzSWhYJ3jFQOrheDApDC1cERCU1UNIwZKXtdYCEZPiud73V0bkpr9TGqSqjnmlGbE2R7RBL1Vu-g7HX-roL361whxo3QcvG1BYSYJsDywqmWFDTVcc-FqWwttayeqrPVunjaaDhqbjY66PRA9_NP7S7UJPxQlAktWZoGXs0AMVyOkQXU-Td7rHsKYlJzWFqSaDnvxH_Lu42bURuf9fe9CHmsnTXVacZ5tYlxm1PIOVH4a6LzN2XM-9w8I1Z5gY0gpgrs5EZdqSu71MmpKrpqTm2nPbttzQ7qOKv0LMODrPg</recordid><startdate>20120217</startdate><enddate>20120217</enddate><creator>Johannsen, Neil M</creator><creator>Swift, Damon L</creator><creator>Johnson, William D</creator><creator>Dixit, Vishwa D</creator><creator>Earnest, Conrad P</creator><creator>Blair, Steven N</creator><creator>Church, Timothy S</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120217</creationdate><title>Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW</title><author>Johannsen, Neil M ; Swift, Damon L ; Johnson, William D ; Dixit, Vishwa D ; Earnest, Conrad P ; Blair, Steven N ; Church, Timothy S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-b92ab84d090fb13233c09023ecff746eca887e698b58f29ed44d62be075518863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adiponectin</topic><topic>Adipose tissue</topic><topic>Aged</topic><topic>Analysis</topic><topic>Anthropometry</topic><topic>Biomarkers</topic><topic>Biomedical research</topic><topic>Blood</topic><topic>Blood cells</topic><topic>Body weight</topic><topic>C-reactive protein</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Chronic illnesses</topic><topic>Clinical trials</topic><topic>Coronary artery disease</topic><topic>Coronary heart disease</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>Dosage</topic><topic>Drug dosages</topic><topic>Energy expenditure</topic><topic>Exercise</topic><topic>Exercise - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johannsen, Neil M</au><au>Swift, Damon L</au><au>Johnson, William D</au><au>Dixit, Vishwa D</au><au>Earnest, Conrad P</au><au>Blair, Steven N</au><au>Church, Timothy S</au><au>Calbet, Jose A. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-02-17</date><risdate>2012</risdate><volume>7</volume><issue>2</issue><spage>e31319</spage><epage>e31319</epage><pages>e31319-e31319</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Elevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total WBC and WBC subfraction counts.
To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-α, C-reactive protein), fasting glucose metabolism, and adiponectin.
Data from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg(-1)⋅week(-1) (KKW) for 6 months at an intensity of 50% VO2peak.
A dose-dependent decrease in total WBC counts (trend P = 0.002) was observed with a significant decrease in the 12KKW group (-163.1±140.0 cells/µL; mean±95%CI) compared with the control (138.6±144.7 cells/µL). A similar response was seen in the neutrophil subfraction (trend P = 0.001) with a significant decrease in the 12KKW group (-152.6±115.1 cells/µL) compared with both the control and 4KKW groups (96.4±119.0 and 21.9±95.3 cells/µL, respectively) and in the 8KKW group (-102.4±125.0 cells/µL) compared with the control. When divided into high/low baseline WBC categories (median split), a dose-dependent decrease in both total WBCs (P = 0.003) and neutrophils (P<0.001) was observed in women with high baseline WBC counts. The effects of exercise dose on total WBC and neutrophil counts persisted after accounting for significant independent effects of change in waist circumference and IL-6.
Aerobic exercise training reduces total WBC and neutrophil counts, in a dose-dependent manner, in overweight/obese postmenopausal women and is especially beneficial for those with systemic low grade inflammation.
NCT00011193.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22363616</pmid><doi>10.1371/journal.pone.0031319</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-02, Vol.7 (2), p.e31319-e31319 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1323571733 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adiponectin Adipose tissue Aged Analysis Anthropometry Biomarkers Biomedical research Blood Blood cells Body weight C-reactive protein Cardiovascular disease Cardiovascular diseases Chronic illnesses Clinical trials Coronary artery disease Coronary heart disease Cytokines Diabetes Disease control Disease prevention Dosage Drug dosages Energy expenditure Exercise Exercise - physiology Fasting Female Fitness Fitness equipment Glucose Glucose - metabolism Health care Health risks Heart Heart diseases Humans Inflammation - pathology Insulin resistance Interleukin 6 Leukocyte Count Leukocytes (neutrophilic) Medical research Medicine Metabolism Middle Aged Monocytes Neutrophils - immunology Obesity Overweight Physical Fitness Physical training Physiological aspects Post-menopause Postmenopausal women Postmenopause - blood Postmenopause - immunology Preventive medicine Protein turnover Public health Quality Statistics, Nonparametric Studies Subcellular Fractions - metabolism Surgeons General Tumor necrosis factor Tumor necrosis factor-α White blood cell count Womens health |
| title | Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A42%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20different%20doses%20of%20aerobic%20exercise%20on%20total%20white%20blood%20cell%20(WBC)%20and%20WBC%20subfraction%20number%20in%20postmenopausal%20women:%20results%20from%20DREW&rft.jtitle=PloS%20one&rft.au=Johannsen,%20Neil%20M&rft.date=2012-02-17&rft.volume=7&rft.issue=2&rft.spage=e31319&rft.epage=e31319&rft.pages=e31319-e31319&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0031319&rft_dat=%3Cgale_plos_%3EA477075679%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1323571733&rft_id=info:pmid/22363616&rft_galeid=A477075679&rft_doaj_id=oai_doaj_org_article_1692e687e45941b3b7a78f5c58ac5f84&rfr_iscdi=true |