Activation of a helper and not regulatory human CD4+ T cell response by oncolytic H-1 parvovirus

H-1 parvovirus (H-1 PV), a rodent autonomous oncolytic parvovirus, has emerged as a novel class of promising anticancer agents, because of its ability to selectively find and destroy malignant cells. However, to probe H-1 PV multimodal antitumor potential one of the major prerequisites is to deciphe...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e32197-e32197
Hauptverfasser:	Moralès, Olivier, Richard, Audrey, Martin, Nathalie, Mrizak, Dhafer, Sénéchal, Magalie, Miroux, Céline, Pancré, Véronique, Rommelaere, Jean, Caillet-Fauquet, Perrine, de Launoit, Yvan, Delhem, Nadira
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anticancer properties Antigens Antitumor agents Biological Therapy - methods Biology Cancer Cancer therapies Carcinoma CD30 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD69 antigen CD8 antigen Cell activation Cytokines Cytometry Cytotoxicity Disease susceptibility Enzyme-linked immunosorbent assay Flow cytometry Garra H-1 parvovirus - immunology Health aspects Humans Immune system Immunosuppression Immunotherapy Infection Infections Interferon Interleukin 2 Interleukin 4 Laboratory animals Leukocytes (mononuclear) Leukocytes (neutrophilic) Life Sciences Lymphocytes Lymphocytes B Lymphocytes T Melanoma Mice Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - therapy Oncolysis Oncolytic viral therapy Oncolytic Viruses - immunology Pancreatic cancer Parvoviruses Peripheral blood mononuclear cells Regulation Subpopulations T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory Vaccines Viability Virions Viruses Western blotting Xenograft Model Antitumor Assays Xenografts γ-Interferon
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