Selective serotonin reuptake inhibitor use is associated with right ventricular structure and function: the MESA-right ventricle study

Serotonin and the serotonin transporter have been implicated in the development of pulmonary hypertension (PH). Selective serotonin reuptake inhibitors (SSRIs) may have a role in PH treatment, but the effects of SSRI use on right ventricular (RV) structure and function are unknown. We hypothesized t...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e30480-e30480
Hauptverfasser:	Ventetuolo, Corey E, Barr, R Graham, Bluemke, David A, Jain, Aditya, Delaney, Joseph A C, Hundley, W Gregory, Lima, Joao A C, Kawut, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antidepressants Antihypertensive agents Apoptosis Arteriosclerosis Atherosclerosis Atherosclerosis - ethnology Atherosclerosis - physiopathology Biology Body mass index Cardiac Volume - drug effects Cardiovascular disease Cardiovascular diseases Confidence intervals Diabetes Diastole - drug effects Drugs Epidemiology Exercise Female Heart Heart diseases Heart Ventricles - anatomy & histology Heart Ventricles - drug effects Heart Ventricles - physiopathology Humans Hypertension Magnetic resonance Magnetic resonance imaging Male Medicine Mental depression Middle Aged NMR Nuclear magnetic resonance Obesity Organ Size - drug effects Phenols (Class of compounds) Physical fitness Pulmonary arteries Pulmonary hypertension Regression analysis Selective serotonin reuptake inhibitors Selective Serotonin Reuptake Inhibitors - pharmacology Serotonin Serotonin transporter Serotonin uptake inhibitors Sex Sex Characteristics Statistical analysis Stroke Stroke volume Stroke Volume - drug effects Structure-function relationships Ventricle Ventricular Function - drug effects
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