A transcriptomic approach to search for novel phenotypic regulators in McArdle disease

McArdle disease is caused by lack of glycogen phosphorylase (GP) activity in skeletal muscle. Patients experience exercise intolerance, presenting as early fatigue and contractures. In this study, we investigated the effects produced by a lack of GP on several genes and proteins of skeletal muscle i...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31718-e31718
Hauptverfasser:	Nogales-Gadea, Gisela, Consuegra-García, Inés, Rubio, Juan C, Arenas, Joaquin, Cuadros, Marc, Camara, Yolanda, Torres-Torronteras, Javier, Fiuza-Luces, Carmen, Lucia, Alejandro, Martín, Miguel A, García-Arumí, Elena, Andreu, Antoni L
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acetyl-CoA carboxylase ATPases Bicycles Biology Ca2+-transporting ATPase Cadherin Cadherins Calcium Calcium (reticular) Calcium transport Calpain Case-Control Studies Climbing Creatine Creatine kinase Disease Electrophoresis Enzymes Exercise Fatigue Gel electrophoresis Gene expression Gene Expression Regulation Genes Glycogen Glycogen phosphorylase Glycogen Phosphorylase - analysis Glycogen Storage Disease Type V - genetics Glycogen Synthase - analysis Glycogen synthase kinase 3 Glycogen synthesis Glycolysis Hoisting Humans Immunoblotting Intolerance Kinases Medical research Medicine Metabolism Multiprotein Complexes - physiology Muscle contraction Muscle Fibers, Fast-Twitch Musculoskeletal system Patients Phenotype Phosphorylase Phosphorylation Physiological aspects Proteins Proteomics Regulators Regulatory mechanisms (biology) Rodents Sarcoplasmic reticulum Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Skeletal muscle Transcriptome Two dimensional analysis Walking
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