The flavonoid luteolin inhibits Fcγ-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice

Bullous pemphigoid is an autoimmune blistering skin disease associated with autoantibodies against the dermal-epidermal junction. Passive transfer of antibodies against BP180/collagen (C) XVII, a major hemidesmosomal pemphigoid antigen, into neonatal mice results in dermal-epidermal separation upon...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31066
Hauptverfasser:	Oswald, Eva, Sesarman, Alina, Franzke, Claus-Werner, Wölfle, Ute, Bruckner-Tuderman, Leena, Jakob, Thilo, Martin, Stefan F, Sitaru, Cassian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal diseases Animal models Animals Antibodies Autoantibodies Autoantigens - immunology Biology Blister - drug therapy Blister - immunology Blistering Bullous pemphigoid Chromatography, Affinity Collagen Collagen Type XVII Complement C3 - metabolism Complement component C3 Dermatology Disease Enzyme-Linked Immunosorbent Assay Female Flavonoids Flow Cytometry Gene expression Granulocytes Granulocytes - drug effects Granulocytes - metabolism Immunization Immunoblotting Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin G - pharmacology Immunoglobulins In vivo methods and tests Inflammation Leukocytes (granulocytic) Luteolin - therapeutic use Ly-6 antigen Matrix Metalloproteinase 9 - metabolism Medical treatment Medicine Mice Mice, Inbred BALB C Mice, Inbred C57BL Neonates Neutrophils Neutrophils - metabolism Non-Fibrillar Collagens - immunology Pemphigoid Pemphigoid, Bullous - chemically induced Pemphigoid, Bullous - drug therapy Pemphigoid, Bullous - immunology Proteins Rabbits Reactive Oxygen Species - metabolism Recruitment Respiratory burst Respiratory Burst - drug effects Rodents Separation Skin diseases Studies
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