Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population
The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. We tested the association between the non-synony...
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| creator | Predazzi, Irene Marta Norata, Giuseppe Danilo Vecchione, Lucia Garlaschelli, Katia Amati, Francesca Grigore, Liliana Cutuli, Lucia Pirillo, Angela Tramontana, Simona Romeo, Francesco Novelli, Giuseppe Catapano, Alberico Luigi |
| description | The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.
We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).
Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.
These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process. |
| doi_str_mv | 10.1371/journal.pone.0031086 |
| format | Article |
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We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).
Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.
These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0031086</identifier><identifier>PMID: 22347434</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amino Acid Substitution ; Analysis ; Arteriosclerosis ; Atherosclerosis ; B cells ; Biology ; Cardiovascular disease ; Carotid arteries ; Carotid artery ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - genetics ; Carotid Artery Diseases - pathology ; Carotid Artery, Common - pathology ; Carriers ; Coronary vessels ; Deoxyribonucleic acid ; DNA ; Epidemiology ; Female ; Functional analysis ; Gene expression ; Genes ; Genetics ; Genotype ; Heart attacks ; Hispanic Americans ; Humans ; Inflammation ; Lectins ; Lesions ; Liquid oxygen ; Low density lipoprotein ; Low density lipoproteins ; LOX-1 protein ; Macrophages ; Male ; Medicine ; Pathogenesis ; Phenols ; Polymorphism, Single Nucleotide ; Population studies ; RNA ; Scavenger receptors ; Scavenger Receptors, Class E - genetics ; Sex Factors ; Single-nucleotide polymorphism ; Studies ; Tunica Intima - pathology ; Tunica Media - pathology ; Variance analysis</subject><ispartof>PloS one, 2012-02, Vol.7 (2), p.e31086</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Predazzi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Predazzi et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-e3713f2b2d939307ff4fc208030442b7d9258677be772db40de4ad7c66ad37213</citedby><cites>FETCH-LOGICAL-c584t-e3713f2b2d939307ff4fc208030442b7d9258677be772db40de4ad7c66ad37213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276570/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276570/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22347434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Predazzi, Irene Marta</creatorcontrib><creatorcontrib>Norata, Giuseppe Danilo</creatorcontrib><creatorcontrib>Vecchione, Lucia</creatorcontrib><creatorcontrib>Garlaschelli, Katia</creatorcontrib><creatorcontrib>Amati, Francesca</creatorcontrib><creatorcontrib>Grigore, Liliana</creatorcontrib><creatorcontrib>Cutuli, Lucia</creatorcontrib><creatorcontrib>Pirillo, Angela</creatorcontrib><creatorcontrib>Tramontana, Simona</creatorcontrib><creatorcontrib>Romeo, Francesco</creatorcontrib><creatorcontrib>Novelli, Giuseppe</creatorcontrib><creatorcontrib>Catapano, Alberico Luigi</creatorcontrib><title>Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.
We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).
Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.
These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.</description><subject>Amino Acid Substitution</subject><subject>Analysis</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>B cells</subject><subject>Biology</subject><subject>Cardiovascular disease</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - genetics</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Carotid Artery, Common - pathology</subject><subject>Carriers</subject><subject>Coronary vessels</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Functional analysis</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Heart attacks</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lectins</subject><subject>Lesions</subject><subject>Liquid oxygen</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>LOX-1 protein</subject><subject>Macrophages</subject><subject>Male</subject><subject>Medicine</subject><subject>Pathogenesis</subject><subject>Phenols</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population studies</subject><subject>RNA</subject><subject>Scavenger receptors</subject><subject>Scavenger Receptors, Class E - genetics</subject><subject>Sex Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><subject>Variance analysis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1UstuEzEUHSEQLYU_QGAJiV2CX2N7NkhRBbRq1CIea8vjR-IwsYPtgPr3OMm0Shas_LjnnnvO1Wma1whOEeHowypuU1DDdBODnUJIEBTsSXOOOoInDEPy9Oh-1rzIeQVhSwRjz5szjAnllNDzpsxyjtqr4mMAvS1_rQ3gbv4NgRvE-C34fvsVqGCAD8WvFVhb4xUoS69_BZsziK4-LNBxva79WqVYvAEqFZvua8--uLDBJjWATdxsh_2gl80zp4ZsX43nRfPz86cfl1eT-d2X68vZfKJbQcvEVpvE4R6bjnQEcueo0xgKSCCluOemw61gnPeWc2x6Co2lynDNmDKEY0QumrcH3s0QsxwXliUimLStEFhUxPUBYaJayU2qHtO9jMrL_UdMC1nNeD1YyTCtWnSHei4oc0owI5wzmva9oS1xlevjOG3b1z1pG0q1fUJ6Wgl-KRfxjySYs5bDSvBuJEjx99bm8h_JI2qhqiofXKxkeu2zljPKOWKo411FvT9CLa0ayjLHYbtbfz4F0gNQp5hzsu5RMIJyF7QHEXIXNDkGrba9OTb72PSQLPIP0UPP1Q</recordid><startdate>20120209</startdate><enddate>20120209</enddate><creator>Predazzi, Irene Marta</creator><creator>Norata, Giuseppe Danilo</creator><creator>Vecchione, Lucia</creator><creator>Garlaschelli, Katia</creator><creator>Amati, Francesca</creator><creator>Grigore, Liliana</creator><creator>Cutuli, Lucia</creator><creator>Pirillo, Angela</creator><creator>Tramontana, Simona</creator><creator>Romeo, Francesco</creator><creator>Novelli, Giuseppe</creator><creator>Catapano, Alberico Luigi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120209</creationdate><title>Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population</title><author>Predazzi, Irene Marta ; Norata, Giuseppe Danilo ; Vecchione, Lucia ; Garlaschelli, Katia ; Amati, Francesca ; Grigore, Liliana ; Cutuli, Lucia ; Pirillo, Angela ; Tramontana, Simona ; Romeo, Francesco ; Novelli, Giuseppe ; Catapano, Alberico Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-e3713f2b2d939307ff4fc208030442b7d9258677be772db40de4ad7c66ad37213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amino Acid Substitution</topic><topic>Analysis</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>B cells</topic><topic>Biology</topic><topic>Cardiovascular disease</topic><topic>Carotid arteries</topic><topic>Carotid artery</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - genetics</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Carotid Artery, Common - pathology</topic><topic>Carriers</topic><topic>Coronary vessels</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Functional analysis</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Heart attacks</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lectins</topic><topic>Lesions</topic><topic>Liquid oxygen</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>LOX-1 protein</topic><topic>Macrophages</topic><topic>Male</topic><topic>Medicine</topic><topic>Pathogenesis</topic><topic>Phenols</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population studies</topic><topic>RNA</topic><topic>Scavenger receptors</topic><topic>Scavenger Receptors, Class E - 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Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.
We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).
Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.
These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22347434</pmid><doi>10.1371/journal.pone.0031086</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-02, Vol.7 (2), p.e31086 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1323558828 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Amino Acid Substitution Analysis Arteriosclerosis Atherosclerosis B cells Biology Cardiovascular disease Carotid arteries Carotid artery Carotid Artery Diseases - epidemiology Carotid Artery Diseases - genetics Carotid Artery Diseases - pathology Carotid Artery, Common - pathology Carriers Coronary vessels Deoxyribonucleic acid DNA Epidemiology Female Functional analysis Gene expression Genes Genetics Genotype Heart attacks Hispanic Americans Humans Inflammation Lectins Lesions Liquid oxygen Low density lipoprotein Low density lipoproteins LOX-1 protein Macrophages Male Medicine Pathogenesis Phenols Polymorphism, Single Nucleotide Population studies RNA Scavenger receptors Scavenger Receptors, Class E - genetics Sex Factors Single-nucleotide polymorphism Studies Tunica Intima - pathology Tunica Media - pathology Variance analysis |
| title | Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T05%3A24%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20OLR1%20K167N%20SNP%20and%20intima%20media%20thickness%20of%20the%20common%20carotid%20artery%20in%20the%20general%20population&rft.jtitle=PloS%20one&rft.au=Predazzi,%20Irene%20Marta&rft.date=2012-02-09&rft.volume=7&rft.issue=2&rft.spage=e31086&rft.pages=e31086-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0031086&rft_dat=%3Cgale_plos_%3EA477161979%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1323558828&rft_id=info:pmid/22347434&rft_galeid=A477161979&rft_doaj_id=oai_doaj_org_article_624f2bc91b7846fa86d8ffdc4bbd453f&rfr_iscdi=true |