Maternal malaria induces a procoagulant and antifibrinolytic state that is embryotoxic but responsive to anticoagulant therapy

Low birth weight and fetal loss are commonly attributed to malaria in endemic areas, but the cellular and molecular mechanisms that underlie these poor birth outcomes are incompletely understood. Increasing evidence suggests that dysregulated hemostasis is important in malaria pathogenesis, but its...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e31090-e31090
Hauptverfasser:	Avery, John W, Smith, Geoffrey M, Owino, Simon O, Sarr, Demba, Nagy, Tamas, Mwalimu, Stephen, Matthias, James, Kelly, Lauren F, Poovassery, Jayakumar S, Middii, Joab D, Abramowsky, Carlos, Moore, Julie M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion Animals Anticoagulants Antifibrinolytic agents Biology Birth Weight Blood Coagulation Childbirth & labor Clinical outcomes Coagulation Deposition Disease prevention Embryos Female Fetuses Fibrin Fibrinolysis Health aspects Hemorrhage Hemostasis Hemostatics Heparin Heparin, Low-Molecular-Weight - therapeutic use Humans Infections Infectious diseases Inflammation Low birth weight Low molecular weights Malaria Malaria - blood Malaria - complications Malaria - drug therapy Markers Medical research Medicine Mice Miscarriage Molecular modelling Molecular weight Monocytes Parasitemia Pathogenesis Pathology Placenta Placenta - blood supply Placenta - parasitology Plasmodium falciparum Pregnancy Pregnancy Complications, Parasitic - blood Pregnancy Complications, Parasitic - drug therapy Pregnant women Thrombophilia - parasitology Treatment Outcome Vector-borne diseases Womens health
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