Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk
Insulin-like growth factors (IGFs) are mediators of growth hormones; they have an influence on cell proliferation and differentiation. In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase I...
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| Veröffentlicht in: | PloS one 2012-02, Vol.7 (2), p.e30951 |
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| creator | Lin, I-Hsin Ho, Ming-Lin Chen, Hsuan-Yu Lee, Hong-Shen Huang, Chia-Chen Chu, Yin-Hung Lin, Shiau-Yun Deng, Ya-Ru He, Yu-Hao Lien, Yu-Hui Hsu, Chi-Wen Wong, Ruey-Hong |
| description | Insulin-like growth factors (IGFs) are mediators of growth hormones; they have an influence on cell proliferation and differentiation. In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3. In this study, we evaluated the effects of smoking, green tea consumption, as well as IGF1, IGF2, and IGFBP3 polymorphisms, on lung cancer risk. Questionnaires were administered to obtain the subjects' characteristics, including smoking habits and green tea consumption from 170 primary lung cancer cases and 340 healthy controls. Genotypes for IGF1, IGF2, and IGFBP3 were identified by polymerase chain reaction. Lung cancer cases had a higher proportion of smoking, green tea consumption of less than one cup per day, exposure to cooking fumes, and family history of lung cancer than controls. After adjusting the confounding effect, an elevated risk was observed in smokers who never drank green tea, as compared to smokers who drank green tea more than one cup per day (odds ratio (OR) = 13.16, 95% confidence interval (CI) = 2.96-58.51). Interaction between smoking and green tea consumption on lung cancer risk was also observed. Among green tea drinkers who drank more than one cup per day, IGF1 (CA)(19)/(CA)(19) and (CA)(19)/X genotypes carriers had a significantly reduced risk of lung cancer (OR = 0.06, 95% CI = 0.01-0.44) compared with IGF1 X/X carriers. Smoking-induced pulmonary carcinogenesis could be modulated by green tea consumption and their growth factor environment. |
| doi_str_mv | 10.1371/journal.pone.0030951 |
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In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3. In this study, we evaluated the effects of smoking, green tea consumption, as well as IGF1, IGF2, and IGFBP3 polymorphisms, on lung cancer risk. Questionnaires were administered to obtain the subjects' characteristics, including smoking habits and green tea consumption from 170 primary lung cancer cases and 340 healthy controls. Genotypes for IGF1, IGF2, and IGFBP3 were identified by polymerase chain reaction. Lung cancer cases had a higher proportion of smoking, green tea consumption of less than one cup per day, exposure to cooking fumes, and family history of lung cancer than controls. After adjusting the confounding effect, an elevated risk was observed in smokers who never drank green tea, as compared to smokers who drank green tea more than one cup per day (odds ratio (OR) = 13.16, 95% confidence interval (CI) = 2.96-58.51). Interaction between smoking and green tea consumption on lung cancer risk was also observed. Among green tea drinkers who drank more than one cup per day, IGF1 (CA)(19)/(CA)(19) and (CA)(19)/X genotypes carriers had a significantly reduced risk of lung cancer (OR = 0.06, 95% CI = 0.01-0.44) compared with IGF1 X/X carriers. Smoking-induced pulmonary carcinogenesis could be modulated by green tea consumption and their growth factor environment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0030951</identifier><identifier>PMID: 22347413</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age Distribution ; Aged ; Biology ; Cancer ; Cancer prevention ; Carcinogenesis ; Carcinogens ; Carriers ; Case-Control Studies ; Cell proliferation ; Chromosomes, Human, X ; Confidence intervals ; Consumption ; Cooking ; Differentiation ; Female ; Fumes ; Gene polymorphism ; Genetic aspects ; Genetic polymorphisms ; Genetics ; Genotype ; Genotypes ; Green tea ; Growth factors ; Growth hormone ; Growth hormones ; Habits ; Health aspects ; Health risk assessment ; Health risks ; Heterozygote ; Hormones ; Humans ; Insulin ; Insulin-Like Growth Factor Binding Protein 3 - genetics ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - genetics ; Insulin-like growth factor II ; Insulin-Like Growth Factor II - genetics ; Insulin-like growth factor-binding protein 3 ; Insulin-like growth factors ; Inventories ; Lung cancer ; Lung diseases ; Lung Neoplasms - epidemiology ; Lung Neoplasms - etiology ; Lung Neoplasms - genetics ; Male ; Medicine ; Middle Aged ; Polymerase chain reaction ; Polymorphism, Genetic ; Polyphenols ; Protein binding ; Risk ; Risk factors ; Risk reduction ; Smoking ; Smoking - adverse effects ; Somatomedins - genetics ; Somatotropin ; Studies ; Surveys and Questionnaires ; Tea</subject><ispartof>PloS one, 2012-02, Vol.7 (2), p.e30951</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Lin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Lin et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c724t-1ff314c8e3f7481669dcf302f2e150f317f5d3c4b955070aa475afbceb7c42193</citedby><cites>FETCH-LOGICAL-c724t-1ff314c8e3f7481669dcf302f2e150f317f5d3c4b955070aa475afbceb7c42193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274549/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274549/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22347413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, I-Hsin</creatorcontrib><creatorcontrib>Ho, Ming-Lin</creatorcontrib><creatorcontrib>Chen, Hsuan-Yu</creatorcontrib><creatorcontrib>Lee, Hong-Shen</creatorcontrib><creatorcontrib>Huang, Chia-Chen</creatorcontrib><creatorcontrib>Chu, Yin-Hung</creatorcontrib><creatorcontrib>Lin, Shiau-Yun</creatorcontrib><creatorcontrib>Deng, Ya-Ru</creatorcontrib><creatorcontrib>He, Yu-Hao</creatorcontrib><creatorcontrib>Lien, Yu-Hui</creatorcontrib><creatorcontrib>Hsu, Chi-Wen</creatorcontrib><creatorcontrib>Wong, Ruey-Hong</creatorcontrib><title>Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Insulin-like growth factors (IGFs) are mediators of growth hormones; they have an influence on cell proliferation and differentiation. In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3. In this study, we evaluated the effects of smoking, green tea consumption, as well as IGF1, IGF2, and IGFBP3 polymorphisms, on lung cancer risk. Questionnaires were administered to obtain the subjects' characteristics, including smoking habits and green tea consumption from 170 primary lung cancer cases and 340 healthy controls. Genotypes for IGF1, IGF2, and IGFBP3 were identified by polymerase chain reaction. Lung cancer cases had a higher proportion of smoking, green tea consumption of less than one cup per day, exposure to cooking fumes, and family history of lung cancer than controls. After adjusting the confounding effect, an elevated risk was observed in smokers who never drank green tea, as compared to smokers who drank green tea more than one cup per day (odds ratio (OR) = 13.16, 95% confidence interval (CI) = 2.96-58.51). Interaction between smoking and green tea consumption on lung cancer risk was also observed. Among green tea drinkers who drank more than one cup per day, IGF1 (CA)(19)/(CA)(19) and (CA)(19)/X genotypes carriers had a significantly reduced risk of lung cancer (OR = 0.06, 95% CI = 0.01-0.44) compared with IGF1 X/X carriers. Smoking-induced pulmonary carcinogenesis could be modulated by green tea consumption and their growth factor environment.</description><subject>Age Distribution</subject><subject>Aged</subject><subject>Biology</subject><subject>Cancer</subject><subject>Cancer prevention</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Carriers</subject><subject>Case-Control Studies</subject><subject>Cell proliferation</subject><subject>Chromosomes, Human, X</subject><subject>Confidence intervals</subject><subject>Consumption</subject><subject>Cooking</subject><subject>Differentiation</subject><subject>Female</subject><subject>Fumes</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Green tea</subject><subject>Growth factors</subject><subject>Growth hormone</subject><subject>Growth hormones</subject><subject>Habits</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heterozygote</subject><subject>Hormones</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - genetics</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-like growth factor II</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Insulin-like growth factor-binding protein 3</subject><subject>Insulin-like growth factors</subject><subject>Inventories</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic</subject><subject>Polyphenols</subject><subject>Protein binding</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Risk reduction</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Somatomedins - genetics</subject><subject>Somatotropin</subject><subject>Studies</subject><subject>Surveys and 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titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, I-Hsin</au><au>Ho, Ming-Lin</au><au>Chen, Hsuan-Yu</au><au>Lee, Hong-Shen</au><au>Huang, Chia-Chen</au><au>Chu, Yin-Hung</au><au>Lin, Shiau-Yun</au><au>Deng, Ya-Ru</au><au>He, Yu-Hao</au><au>Lien, Yu-Hui</au><au>Hsu, Chi-Wen</au><au>Wong, Ruey-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-02-07</date><risdate>2012</risdate><volume>7</volume><issue>2</issue><spage>e30951</spage><pages>e30951-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Insulin-like growth factors (IGFs) are mediators of growth hormones; they have an influence on cell proliferation and differentiation. In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3. In this study, we evaluated the effects of smoking, green tea consumption, as well as IGF1, IGF2, and IGFBP3 polymorphisms, on lung cancer risk. Questionnaires were administered to obtain the subjects' characteristics, including smoking habits and green tea consumption from 170 primary lung cancer cases and 340 healthy controls. Genotypes for IGF1, IGF2, and IGFBP3 were identified by polymerase chain reaction. Lung cancer cases had a higher proportion of smoking, green tea consumption of less than one cup per day, exposure to cooking fumes, and family history of lung cancer than controls. After adjusting the confounding effect, an elevated risk was observed in smokers who never drank green tea, as compared to smokers who drank green tea more than one cup per day (odds ratio (OR) = 13.16, 95% confidence interval (CI) = 2.96-58.51). Interaction between smoking and green tea consumption on lung cancer risk was also observed. Among green tea drinkers who drank more than one cup per day, IGF1 (CA)(19)/(CA)(19) and (CA)(19)/X genotypes carriers had a significantly reduced risk of lung cancer (OR = 0.06, 95% CI = 0.01-0.44) compared with IGF1 X/X carriers. Smoking-induced pulmonary carcinogenesis could be modulated by green tea consumption and their growth factor environment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22347413</pmid><doi>10.1371/journal.pone.0030951</doi><tpages>e30951</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-02, Vol.7 (2), p.e30951 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1323558367 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Distribution Aged Biology Cancer Cancer prevention Carcinogenesis Carcinogens Carriers Case-Control Studies Cell proliferation Chromosomes, Human, X Confidence intervals Consumption Cooking Differentiation Female Fumes Gene polymorphism Genetic aspects Genetic polymorphisms Genetics Genotype Genotypes Green tea Growth factors Growth hormone Growth hormones Habits Health aspects Health risk assessment Health risks Heterozygote Hormones Humans Insulin Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-like growth factor II Insulin-Like Growth Factor II - genetics Insulin-like growth factor-binding protein 3 Insulin-like growth factors Inventories Lung cancer Lung diseases Lung Neoplasms - epidemiology Lung Neoplasms - etiology Lung Neoplasms - genetics Male Medicine Middle Aged Polymerase chain reaction Polymorphism, Genetic Polyphenols Protein binding Risk Risk factors Risk reduction Smoking Smoking - adverse effects Somatomedins - genetics Somatotropin Studies Surveys and Questionnaires Tea |
| title | Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T10%3A47%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Smoking,%20green%20tea%20consumption,%20genetic%20polymorphisms%20in%20the%20insulin-like%20growth%20factors%20and%20lung%20cancer%20risk&rft.jtitle=PloS%20one&rft.au=Lin,%20I-Hsin&rft.date=2012-02-07&rft.volume=7&rft.issue=2&rft.spage=e30951&rft.pages=e30951-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0030951&rft_dat=%3Cgale_plos_%3EA477162127%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1323558367&rft_id=info:pmid/22347413&rft_galeid=A477162127&rft_doaj_id=oai_doaj_org_article_5b9c85a99c484de29774ecc88a597918&rfr_iscdi=true |