Alternaria-induced release of IL-18 from damaged airway epithelial cells: an NF-κB dependent mechanism of Th2 differentiation?

A series of epidemiologic studies have identified the fungus Alternaria as a major risk factor for asthma. The airway epithelium plays a critical role in the pathogenesis of allergic asthma. These reports suggest that activated airway epithelial cells can produce cytokines such as IL-25, TSLP and IL...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e30280-e30280
Hauptverfasser:	Murai, Hiroki, Qi, Huibin, Choudhury, Barun, Wild, Jim, Dharajiya, Nilesh, Vaidya, Swapnil, Kalita, Anjana, Bacsi, Attila, Corry, David, Kurosky, Alexander, Brasier, Allan, Boldogh, Istvan, Sur, Sanjiv
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Allergies Alternaria - immunology Animals Antigens Asthma Biology CD4 antigen Cell culture Cell Differentiation - immunology Cells, Cultured Cytokines Cytokines - analysis Damage Dendritic cells Differentiation Drug dosages Enzyme-linked immunosorbent assay Epidemiology Epithelial cells Epithelial Cells - immunology Epithelial Cells - microbiology Epithelial Cells - pathology Epithelium Flow cytometry Fungi Humans Inflammation Interleukin 13 Interleukin 18 Interleukin 4 Interleukin 9 Interleukin-18 - immunology Interleukin-18 - metabolism Internal medicine Lolium perenne Lymphocytes Lymphocytes T Medicine Mice Necrosis NF-kappa B - immunology NF-κB protein Pathogenesis Penicillium Respiratory System - immunology Respiratory System - microbiology Respiratory System - pathology Respiratory tract Risk factors Stat6 protein Studies Th2 Cells - immunology Th2 Cells - pathology Thymic stromal lymphopoietin
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