Hazardous alcohol consumption is a major factor in male premature mortality in a typical Russian city: prospective cohort study 2003-2009
Russia has experienced massive fluctuations in mortality at working ages over the past three decades. Routine data analyses suggest that these are largely driven by fluctuations in heavy alcohol drinking. However, individual-level evidence supporting alcohol having a major role in Russian mortality...
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| creator | Tomkins, Susannah Collier, Tim Oralov, Alexey Saburova, Lyudmila McKee, Martin Shkolnikov, Vladimir Kiryanov, Nikolay Leon, David A |
| description | Russia has experienced massive fluctuations in mortality at working ages over the past three decades. Routine data analyses suggest that these are largely driven by fluctuations in heavy alcohol drinking. However, individual-level evidence supporting alcohol having a major role in Russian mortality comes from only two case-control studies, which could be subject to serious biases due to their design.
A prospective study of mortality (2003-9) of 2000 men aged 25-54 years at recruitment was conducted in the city of Izhevsk, Russia. This cohort was free from key limitations inherent in the design of the two earlier case-control studies. Cox proportional hazards regression was used to estimate hazard ratios of all-cause mortality by alcohol drinking type as reported by a proxy informant. Hazardous drinkers were defined as those who either drank non-beverage alcohols or were reported to regularly have hangovers or other behaviours related to heavy drinking episodes. Over the follow-up period 113 men died. Compared to non-hazardous drinkers and abstainers, men who drank hazardously had appreciably higher mortality (HR = 3.4, 95% CI 2.2, 5.1) adjusted for age, smoking and education. The population attributable risk percent (PAR%) for hazardous drinking was 26% (95% CI 14,37). However, larger effects were seen in the first two years of follow-up, with a HR of 4.6 (2.5, 8.2) and a corresponding PAR% of 37% (17, 51).
This prospective cohort study strengthens the evidence that hazardous alcohol consumption has been a major determinant of mortality among working age men in a typical Russian city. As such the similar findings of the previous case-control studies cannot be explained as artefacts of limitations of their design. As Russia struggles to raise life expectancy, which even in 2009 was only 62 years among men, control of hazardous drinking must remain a top public health priority. |
| doi_str_mv | 10.1371/journal.pone.0030274 |
| format | Article |
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A prospective study of mortality (2003-9) of 2000 men aged 25-54 years at recruitment was conducted in the city of Izhevsk, Russia. This cohort was free from key limitations inherent in the design of the two earlier case-control studies. Cox proportional hazards regression was used to estimate hazard ratios of all-cause mortality by alcohol drinking type as reported by a proxy informant. Hazardous drinkers were defined as those who either drank non-beverage alcohols or were reported to regularly have hangovers or other behaviours related to heavy drinking episodes. Over the follow-up period 113 men died. Compared to non-hazardous drinkers and abstainers, men who drank hazardously had appreciably higher mortality (HR = 3.4, 95% CI 2.2, 5.1) adjusted for age, smoking and education. The population attributable risk percent (PAR%) for hazardous drinking was 26% (95% CI 14,37). However, larger effects were seen in the first two years of follow-up, with a HR of 4.6 (2.5, 8.2) and a corresponding PAR% of 37% (17, 51).
This prospective cohort study strengthens the evidence that hazardous alcohol consumption has been a major determinant of mortality among working age men in a typical Russian city. As such the similar findings of the previous case-control studies cannot be explained as artefacts of limitations of their design. As Russia struggles to raise life expectancy, which even in 2009 was only 62 years among men, control of hazardous drinking must remain a top public health priority.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0030274</identifier><identifier>PMID: 22347371</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol Drinking - mortality ; Alcohol use ; Alcoholic beverages ; Alcohols ; Analysis ; Artefacts ; Biology ; Cities ; Cohort analysis ; Cohort Studies ; Consumption ; Data processing ; Design ; Drinking ; Drinking (Alcoholic beverages) ; Drinking behavior ; Ethanol ; Fluctuations ; Follow-Up Studies ; Hazards ; Health aspects ; Humans ; Hygiene ; Hypotheses ; Information management ; Life Expectancy ; Life span ; Male ; Medicine ; Men ; Mens health ; Middle age ; Morality ; Mortality ; Mortality, Premature ; Political economy ; Population ; Premature mortality ; Prospective Studies ; Public health ; Recruitment ; Regression analysis ; Russia - epidemiology ; Sex Factors ; Smoking ; Social and Behavioral Sciences ; Studies</subject><ispartof>PloS one, 2012-02, Vol.7 (2), p.e30274-e30274</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Tomkins et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Tomkins et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-89e75c941a5bb6f79364d28adc6353fb921a3d86a7ccf9f1b01b571b6301299a3</citedby><cites>FETCH-LOGICAL-c757t-89e75c941a5bb6f79364d28adc6353fb921a3d86a7ccf9f1b01b571b6301299a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275563/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275563/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22347371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hernandez, Adrian V.</contributor><creatorcontrib>Tomkins, Susannah</creatorcontrib><creatorcontrib>Collier, Tim</creatorcontrib><creatorcontrib>Oralov, Alexey</creatorcontrib><creatorcontrib>Saburova, Lyudmila</creatorcontrib><creatorcontrib>McKee, Martin</creatorcontrib><creatorcontrib>Shkolnikov, Vladimir</creatorcontrib><creatorcontrib>Kiryanov, Nikolay</creatorcontrib><creatorcontrib>Leon, David A</creatorcontrib><title>Hazardous alcohol consumption is a major factor in male premature mortality in a typical Russian city: prospective cohort study 2003-2009</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Russia has experienced massive fluctuations in mortality at working ages over the past three decades. Routine data analyses suggest that these are largely driven by fluctuations in heavy alcohol drinking. However, individual-level evidence supporting alcohol having a major role in Russian mortality comes from only two case-control studies, which could be subject to serious biases due to their design.
A prospective study of mortality (2003-9) of 2000 men aged 25-54 years at recruitment was conducted in the city of Izhevsk, Russia. This cohort was free from key limitations inherent in the design of the two earlier case-control studies. Cox proportional hazards regression was used to estimate hazard ratios of all-cause mortality by alcohol drinking type as reported by a proxy informant. Hazardous drinkers were defined as those who either drank non-beverage alcohols or were reported to regularly have hangovers or other behaviours related to heavy drinking episodes. Over the follow-up period 113 men died. Compared to non-hazardous drinkers and abstainers, men who drank hazardously had appreciably higher mortality (HR = 3.4, 95% CI 2.2, 5.1) adjusted for age, smoking and education. The population attributable risk percent (PAR%) for hazardous drinking was 26% (95% CI 14,37). However, larger effects were seen in the first two years of follow-up, with a HR of 4.6 (2.5, 8.2) and a corresponding PAR% of 37% (17, 51).
This prospective cohort study strengthens the evidence that hazardous alcohol consumption has been a major determinant of mortality among working age men in a typical Russian city. As such the similar findings of the previous case-control studies cannot be explained as artefacts of limitations of their design. As Russia struggles to raise life expectancy, which even in 2009 was only 62 years among men, control of hazardous drinking must remain a top public health priority.</description><subject>Adult</subject><subject>Age</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol Drinking - mortality</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Analysis</subject><subject>Artefacts</subject><subject>Biology</subject><subject>Cities</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Consumption</subject><subject>Data processing</subject><subject>Design</subject><subject>Drinking</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Drinking behavior</subject><subject>Ethanol</subject><subject>Fluctuations</subject><subject>Follow-Up Studies</subject><subject>Hazards</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Hypotheses</subject><subject>Information management</subject><subject>Life Expectancy</subject><subject>Life span</subject><subject>Male</subject><subject>Medicine</subject><subject>Men</subject><subject>Mens health</subject><subject>Middle age</subject><subject>Morality</subject><subject>Mortality</subject><subject>Mortality, Premature</subject><subject>Political economy</subject><subject>Population</subject><subject>Premature mortality</subject><subject>Prospective Studies</subject><subject>Public health</subject><subject>Recruitment</subject><subject>Regression analysis</subject><subject>Russia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomkins, Susannah</au><au>Collier, Tim</au><au>Oralov, Alexey</au><au>Saburova, Lyudmila</au><au>McKee, Martin</au><au>Shkolnikov, Vladimir</au><au>Kiryanov, Nikolay</au><au>Leon, David A</au><au>Hernandez, Adrian V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hazardous alcohol consumption is a major factor in male premature mortality in a typical Russian city: prospective cohort study 2003-2009</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-02-08</date><risdate>2012</risdate><volume>7</volume><issue>2</issue><spage>e30274</spage><epage>e30274</epage><pages>e30274-e30274</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Russia has experienced massive fluctuations in mortality at working ages over the past three decades. Routine data analyses suggest that these are largely driven by fluctuations in heavy alcohol drinking. However, individual-level evidence supporting alcohol having a major role in Russian mortality comes from only two case-control studies, which could be subject to serious biases due to their design.
A prospective study of mortality (2003-9) of 2000 men aged 25-54 years at recruitment was conducted in the city of Izhevsk, Russia. This cohort was free from key limitations inherent in the design of the two earlier case-control studies. Cox proportional hazards regression was used to estimate hazard ratios of all-cause mortality by alcohol drinking type as reported by a proxy informant. Hazardous drinkers were defined as those who either drank non-beverage alcohols or were reported to regularly have hangovers or other behaviours related to heavy drinking episodes. Over the follow-up period 113 men died. Compared to non-hazardous drinkers and abstainers, men who drank hazardously had appreciably higher mortality (HR = 3.4, 95% CI 2.2, 5.1) adjusted for age, smoking and education. The population attributable risk percent (PAR%) for hazardous drinking was 26% (95% CI 14,37). However, larger effects were seen in the first two years of follow-up, with a HR of 4.6 (2.5, 8.2) and a corresponding PAR% of 37% (17, 51).
This prospective cohort study strengthens the evidence that hazardous alcohol consumption has been a major determinant of mortality among working age men in a typical Russian city. As such the similar findings of the previous case-control studies cannot be explained as artefacts of limitations of their design. As Russia struggles to raise life expectancy, which even in 2009 was only 62 years among men, control of hazardous drinking must remain a top public health priority.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22347371</pmid><doi>10.1371/journal.pone.0030274</doi><tpages>e30274</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2012-02, Vol.7 (2), p.e30274-e30274 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Age Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol Drinking - mortality Alcohol use Alcoholic beverages Alcohols Analysis Artefacts Biology Cities Cohort analysis Cohort Studies Consumption Data processing Design Drinking Drinking (Alcoholic beverages) Drinking behavior Ethanol Fluctuations Follow-Up Studies Hazards Health aspects Humans Hygiene Hypotheses Information management Life Expectancy Life span Male Medicine Men Mens health Middle age Morality Mortality Mortality, Premature Political economy Population Premature mortality Prospective Studies Public health Recruitment Regression analysis Russia - epidemiology Sex Factors Smoking Social and Behavioral Sciences Studies |
| title | Hazardous alcohol consumption is a major factor in male premature mortality in a typical Russian city: prospective cohort study 2003-2009 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A47%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hazardous%20alcohol%20consumption%20is%20a%20major%20factor%20in%20male%20premature%20mortality%20in%20a%20typical%20Russian%20city:%20prospective%20cohort%20study%202003-2009&rft.jtitle=PloS%20one&rft.au=Tomkins,%20Susannah&rft.date=2012-02-08&rft.volume=7&rft.issue=2&rft.spage=e30274&rft.epage=e30274&rft.pages=e30274-e30274&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0030274&rft_dat=%3Cgale_plos_%3EA477162061%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1323550925&rft_id=info:pmid/22347371&rft_galeid=A477162061&rft_doaj_id=oai_doaj_org_article_2b9d3467ccf14da887c6ba5da0ce1fd6&rfr_iscdi=true |