Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus

Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis. Here we show that genetic ablation of NF-κB resulted in severe defects in the neurogenic region (dentate gyrus) of th...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e30838
Hauptverfasser:	Imielski, Yvonne, Schwamborn, Jens C, Lüningschrör, Patrick, Heimann, Peter, Holzberg, Magdalena, Werner, Hendrikje, Leske, Oliver, Püschel, Andreas W, Memet, Sylvie, Heumann, Rolf, Israel, Alain, Kaltschmidt, Christian, Kaltschmidt, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aging Alzheimer's disease Animals Apoptosis Atrophy Biology Brain Cell cycle Cell growth Cell proliferation Cognitive ability Cyclic AMP-Dependent Protein Kinases - metabolism Data recovery Defects Dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - metabolism Dentate Gyrus - physiology Deoxyribonucleic acid Disruption DNA Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FOXO1 protein Gene Deletion Gene Expression Regulation Hippocampus Homeostasis Inflammation - metabolism Inflammation - pathology Inflammation - physiopathology Kinases Localization Male Memory Mice Mood Mossy Fibers, Hippocampal - metabolism Mossy Fibers, Hippocampal - physiology Nerve Net - cytology Nerve Net - metabolism Nerve Net - physiology Neurobiology Neurogenesis Neurons Neuroprotection Neurosciences NF-kappa B - deficiency NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Pathology Physiology Proteins Regeneration Rodents Signal Transduction Spatial Behavior - physiology Stem cells Synaptogenesis Transcription
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