Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner

Cytochomosome P450 enzymes (CYP) are heme-containing monooxygenases responsible for oxidative metabolism of many exogenous and endogenous compounds including drugs. The species difference of CYP limits the extent to which data obtained from animals can be translated to humans in pharmacodynamics or...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30560
Hauptverfasser:	Wang, Yong, Hu, Hai-Hong, Pang, Hao, Zhou, Xiao-Yang, Yu, Lu-Shan, Wang, Lu-Lu, Liu, Cang'e, Guo, Ke-Nan, Zhao, Cong, Liu, Qin, Zeng, Ben-Hua, Tang, Huan, Shang, Hai-Tao, Zeng, Su, Wei, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anemia Animal genetic engineering Animal sciences Animals Biology Cells, Cultured Cytochrome Cytochrome P-450 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - genetics Data processing Deoxyribonucleic acid DNA Dose-Response Relationship, Drug Drugs Enzymatic activity Enzymes Female Gene Dosage - physiology Gene expression Genetic Vectors - genetics Heme Humans Huntingtons disease Inheritance Patterns - drug effects Inheritance Patterns - genetics Inheritance Patterns - physiology Laboratory animals Lentivirus - genetics Male Medicine Metabolism Mice Mice, Transgenic MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - pharmacology miRNA Monkeys & apes Offspring Oxidative metabolism Pharmaceutical sciences Pharmacodynamics Pharmacokinetics Pharmacology Pharmacy Polymerase chain reaction Ribonucleic acid RNA RNA Interference - drug effects RNA Interference - physiology RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Rodents Species Stem cells Transcription Transgenic mice Zoology
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