PET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-nitroso-diethylamine as carcinogen in a short-term cancer bioassay

More than 100,000 chemicals are in use but have not been tested for their safety. To overcome limitations in the cancer bioassay several alternative testing strategies are explored. The inability to monitor non-invasively onset and progression of disease limits, however, the value of current testing...

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Veröffentlicht in:	PloS one 2012-02, Vol.7 (2), p.e30432
Hauptverfasser:	Hueper, Katja, Elalfy, Mahmoud, Laenger, Florian, Halter, Roman, Rodt, Thomas, Galanski, Michael, Borlak, Juergen
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animal genetic engineering Animal models Animals Bioassays Biotechnology c-Myc protein Cancer Cancer metastasis Carcinogens Carcinogens - toxicity CAT scans Cell Proliferation Chemicals Computed tomography Diagnostic Imaging - methods Diagnostic Imaging - standards Diethylnitrosamine - toxicity Disease control Drug dosages Enzymes Gene expression Genetically modified animals Genotoxicity Glucose - metabolism Growth factors Hazard identification Hepatotoxicity Histochemistry Histopathology Identification methods Imaging Imaging techniques In vivo methods and tests Laboratory animals Lesions Liver Liver cancer Liver Neoplasms - chemically induced Liver Neoplasms - diagnosis Liver Neoplasms - pathology Lung cancer Lung diseases Medical imaging Medical schools Medicine Metabolism Metabolites Metastases Mice Mice, Transgenic Multimodal Imaging Myc protein Neoplasm Metastasis Organs Paracetamol Pathology Positron emission Positron emission tomography Proto-Oncogene Proteins c-myc - genetics Rodents Short term Studies Tomography Tomography, X-Ray Computed Toxicology Transgenic animals Transgenic mice Tumor Burden Tumors
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