Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state

To identify novel biomarkers for HIV-1 resistance, including pathways that may be critical in anti-HIV-1 vaccine design, we carried out a gene expression analysis on blood samples obtained from HIV-1 highly exposed seronegatives (HESN) from a commercial sex worker cohort in Nairobi and compared thei...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30048-e30048
Hauptverfasser:	Songok, Elijah M, Luo, Ma, Liang, Ben, Mclaren, Paul, Kaefer, Nadine, Apidi, Winnie, Boucher, Genevieve, Kimani, Joshua, Wachihi, Charles, Sekaly, Rafick, Fowke, Keith, Ball, Blake T, Plummer, Francis A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS vaccines Antiviral agents Biology Biomarkers Blood Cell adhesion & migration Chemokines Cluster Analysis Clustering Cohort Studies Comparative analysis Cytokines Cytotoxicity Data processing DNA microarrays Down-Regulation - genetics Down-Regulation - immunology Female Gene expression Gene Expression Profiling Gene regulation Genes Genomes Gluconeogenesis Glycolysis Health aspects HIV HIV Infections - genetics HIV Infections - immunology HIV-1 - immunology Human immunodeficiency virus Humans Hybridization Immune response Immunity, Innate - genetics Infections Kenya Killer cells Ligands Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytes T Medicine Microarray Analysis Natural killer cells Pathogenesis Pentose Pentose phosphate pathway Phosphates Prostitution Protein biosynthesis Protein synthesis Public health Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Sex Sex industry Sex oriented businesses Sex Workers Sexually transmitted diseases Signal transduction Signaling STD T cell receptors T cells T-cell receptor Toxicity Type 2 diabetes Validation Studies as Topic Viruses Workers Working women
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