Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains

Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30292-e30292
Hauptverfasser:	Sucupira, Maria Cecilia Araripe, Sanabani, Sabri, Cortes, Rodrigo M, Giret, Maria Teresa M, Tomiyama, Helena, Sauer, Mariana M, Sabino, Ester Cerdeira, Janini, Luiz Mario, Kallas, Esper Georges, Diaz, Ricardo Sobhie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Algorithms Amino Acid Sequence Amino acids Antiretroviral drugs Binding Sites Biology Brazil CCR5 protein CD4 antigen Cohort Studies CXCR4 protein Demographics Development and progression Disease Progression Emergence Female Health aspects HIV HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - metabolism HIV infections HIV Infections - diagnosis HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV patients HIV tests HIV-1 - genetics HIV-1 - immunology HIV-1 - metabolism HIV-1 - physiology Human immunodeficiency virus Humans Infection Infections Lymphocytes T Male Medical treatment Medicine Middle Aged Molecular Sequence Data Mutation Pathogenicity Pathogens Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Receptors, CXCR4 - immunology Receptors, CXCR4 - metabolism Receptors, Virus - metabolism Sequence Homology, Amino Acid Seroconversion Strains (organisms) T cells Time Factors Virus Internalization Viruses Young Adult
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