Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains
Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the...
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| Veröffentlicht in: | PloS one 2012-01, Vol.7 (1), p.e30292-e30292 |
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| creator | Sucupira, Maria Cecilia Araripe Sanabani, Sabri Cortes, Rodrigo M Giret, Maria Teresa M Tomiyama, Helena Sauer, Mariana M Sabino, Ester Cerdeira Janini, Luiz Mario Kallas, Esper Georges Diaz, Ricardo Sobhie |
| description | Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.
A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. The HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/µL.
Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4>350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.
Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions. |
| doi_str_mv | 10.1371/journal.pone.0030292 |
| format | Article |
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A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. The HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/µL.
Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4<350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4>350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4>350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.
Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0030292</identifier><identifier>PMID: 22291931</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Algorithms ; Amino Acid Sequence ; Amino acids ; Antiretroviral drugs ; Binding Sites ; Biology ; Brazil ; CCR5 protein ; CD4 antigen ; Cohort Studies ; CXCR4 protein ; Demographics ; Development and progression ; Disease Progression ; Emergence ; Female ; Health aspects ; HIV ; HIV Envelope Protein gp120 - chemistry ; HIV Envelope Protein gp120 - genetics ; HIV Envelope Protein gp120 - metabolism ; HIV infections ; HIV Infections - diagnosis ; HIV Infections - genetics ; HIV Infections - immunology ; HIV Infections - virology ; HIV patients ; HIV tests ; HIV-1 - genetics ; HIV-1 - immunology ; HIV-1 - metabolism ; HIV-1 - physiology ; Human immunodeficiency virus ; Humans ; Infection ; Infections ; Lymphocytes T ; Male ; Medical treatment ; Medicine ; Middle Aged ; Molecular Sequence Data ; Mutation ; Pathogenicity ; Pathogens ; Peptide Fragments - chemistry ; Peptide Fragments - genetics ; Peptide Fragments - metabolism ; Receptors, CXCR4 - immunology ; Receptors, CXCR4 - metabolism ; Receptors, Virus - metabolism ; Sequence Homology, Amino Acid ; Seroconversion ; Strains (organisms) ; T cells ; Time Factors ; Virus Internalization ; Viruses ; Young Adult</subject><ispartof>PloS one, 2012-01, Vol.7 (1), p.e30292-e30292</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Sucupira et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Sucupira et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-8e6d22dde6614847f08d2aa596a45fe2359ff0773b0e64fbacb9a5855d10bcd93</citedby><cites>FETCH-LOGICAL-c691t-8e6d22dde6614847f08d2aa596a45fe2359ff0773b0e64fbacb9a5855d10bcd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266896/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266896/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22291931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Poehlmann, Stefan</contributor><creatorcontrib>Sucupira, Maria Cecilia Araripe</creatorcontrib><creatorcontrib>Sanabani, Sabri</creatorcontrib><creatorcontrib>Cortes, Rodrigo M</creatorcontrib><creatorcontrib>Giret, Maria Teresa M</creatorcontrib><creatorcontrib>Tomiyama, Helena</creatorcontrib><creatorcontrib>Sauer, Mariana M</creatorcontrib><creatorcontrib>Sabino, Ester Cerdeira</creatorcontrib><creatorcontrib>Janini, Luiz Mario</creatorcontrib><creatorcontrib>Kallas, Esper Georges</creatorcontrib><creatorcontrib>Diaz, Ricardo Sobhie</creatorcontrib><title>Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.
A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. The HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/µL.
Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4<350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4>350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4>350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.
Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Algorithms</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Antiretroviral drugs</subject><subject>Binding Sites</subject><subject>Biology</subject><subject>Brazil</subject><subject>CCR5 protein</subject><subject>CD4 antigen</subject><subject>Cohort Studies</subject><subject>CXCR4 protein</subject><subject>Demographics</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Emergence</subject><subject>Female</subject><subject>Health aspects</subject><subject>HIV</subject><subject>HIV Envelope Protein gp120 - chemistry</subject><subject>HIV Envelope Protein gp120 - genetics</subject><subject>HIV Envelope Protein gp120 - metabolism</subject><subject>HIV infections</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV patients</subject><subject>HIV tests</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - immunology</subject><subject>HIV-1 - metabolism</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infection</subject><subject>Infections</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Peptide Fragments - chemistry</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - metabolism</subject><subject>Receptors, CXCR4 - immunology</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Receptors, Virus - metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Seroconversion</subject><subject>Strains (organisms)</subject><subject>T cells</subject><subject>Time Factors</subject><subject>Virus Internalization</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQgJxyOLvJBeksqJ0pUqVClTcLCeeZL1k463tFNpfj5dNqw3qAfkQa_y87zgzniR5idEM0xx_WNnB9aqbbWwPM4QoIiV5lBzikpJMEEQf7-0PkmferxDitBDiaXJACCnjIT5Mfp4oH8Clp4vLDKfaeFAe0o2zrQPvje1TtbZ9m35y6tZ0RvWp6bW5NnpQnU8d1NCH7iYGG6gD6PSXCct0_mN-wbIhRMGtiWIfnDK9f548aaIKXozfo-T7yedv89Ps7PzLYn58ltWixCErQGhCtAYhMCtY3qBCE6V4KRTjDRDKy6ZBeU4rBII1laqrUvGCc41RVeuSHiWvd76bzno51slLTAlllHKcR2KxI7RVK7lxZq3cjbTKyL8B61qpXDB1B5KjhucFL3HVFAyxooIcaEWxIJwThnX0-jhmG6o16G1BnOomptOT3ixla68lJUIUpYgG70YDZ68G8EGuja-h61QPdvAydoqQXKDttd_8Qz78cyPVqnj_2Bkb09ZbT3nM8hwxRPg26-wBKi4Na1PHN9WYGJ8I3k8EkQnwO7Rq8F4uvl78P3t-OWXf7rFLUF1YetvF12N7PwXZDqyd9d5Bc19jjOR2JO6qIbcjIceRiLJX-_25F93NAP0DzoEGJg</recordid><startdate>20120126</startdate><enddate>20120126</enddate><creator>Sucupira, Maria Cecilia Araripe</creator><creator>Sanabani, Sabri</creator><creator>Cortes, Rodrigo M</creator><creator>Giret, Maria Teresa M</creator><creator>Tomiyama, Helena</creator><creator>Sauer, Mariana M</creator><creator>Sabino, Ester Cerdeira</creator><creator>Janini, Luiz Mario</creator><creator>Kallas, Esper Georges</creator><creator>Diaz, Ricardo Sobhie</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120126</creationdate><title>Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains</title><author>Sucupira, Maria Cecilia Araripe ; Sanabani, Sabri ; Cortes, Rodrigo M ; Giret, Maria Teresa M ; Tomiyama, Helena ; Sauer, Mariana M ; Sabino, Ester Cerdeira ; Janini, Luiz Mario ; Kallas, Esper Georges ; Diaz, Ricardo Sobhie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-8e6d22dde6614847f08d2aa596a45fe2359ff0773b0e64fbacb9a5855d10bcd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>Algorithms</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Antiretroviral drugs</topic><topic>Binding Sites</topic><topic>Biology</topic><topic>Brazil</topic><topic>CCR5 protein</topic><topic>CD4 antigen</topic><topic>Cohort Studies</topic><topic>CXCR4 protein</topic><topic>Demographics</topic><topic>Development and progression</topic><topic>Disease Progression</topic><topic>Emergence</topic><topic>Female</topic><topic>Health aspects</topic><topic>HIV</topic><topic>HIV Envelope Protein gp120 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sucupira, Maria Cecilia Araripe</au><au>Sanabani, Sabri</au><au>Cortes, Rodrigo M</au><au>Giret, Maria Teresa M</au><au>Tomiyama, Helena</au><au>Sauer, Mariana M</au><au>Sabino, Ester Cerdeira</au><au>Janini, Luiz Mario</au><au>Kallas, Esper Georges</au><au>Diaz, Ricardo Sobhie</au><au>Poehlmann, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-01-26</date><risdate>2012</risdate><volume>7</volume><issue>1</issue><spage>e30292</spage><epage>e30292</epage><pages>e30292-e30292</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.
A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. The HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/µL.
Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4<350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4>350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4>350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.
Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22291931</pmid><doi>10.1371/journal.pone.0030292</doi><tpages>e30292</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-01, Vol.7 (1), p.e30292-e30292 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1323433517 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acquired immune deficiency syndrome Adult AIDS Algorithms Amino Acid Sequence Amino acids Antiretroviral drugs Binding Sites Biology Brazil CCR5 protein CD4 antigen Cohort Studies CXCR4 protein Demographics Development and progression Disease Progression Emergence Female Health aspects HIV HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - metabolism HIV infections HIV Infections - diagnosis HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV patients HIV tests HIV-1 - genetics HIV-1 - immunology HIV-1 - metabolism HIV-1 - physiology Human immunodeficiency virus Humans Infection Infections Lymphocytes T Male Medical treatment Medicine Middle Aged Molecular Sequence Data Mutation Pathogenicity Pathogens Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Receptors, CXCR4 - immunology Receptors, CXCR4 - metabolism Receptors, Virus - metabolism Sequence Homology, Amino Acid Seroconversion Strains (organisms) T cells Time Factors Virus Internalization Viruses Young Adult |
| title | Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T23%3A31%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Faster%20HIV-1%20disease%20progression%20among%20Brazilian%20individuals%20recently%20infected%20with%20CXCR4-utilizing%20strains&rft.jtitle=PloS%20one&rft.au=Sucupira,%20Maria%20Cecilia%20Araripe&rft.date=2012-01-26&rft.volume=7&rft.issue=1&rft.spage=e30292&rft.epage=e30292&rft.pages=e30292-e30292&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0030292&rft_dat=%3Cgale_plos_%3EA477040256%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1323433517&rft_id=info:pmid/22291931&rft_galeid=A477040256&rft_doaj_id=oai_doaj_org_article_50f578591bf84048be7e3b316255241d&rfr_iscdi=true |