Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus

Swine influenza is an acute respiratory disease in pigs caused by swine influenza virus (SIV). Highly virulent SIV strains cause mortality of up to 10%. Importantly, pigs have long been considered "mixing vessels" that generate novel influenza viruses with pandemic potential, a constant th...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30328
Hauptverfasser:	Gao, Wei, Sun, Wenkui, Qu, Bingqian, Cardona, Carol J, Powell, Kira, Wegner, Marta, Shi, Yi, Xing, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral agents Apoptosis Biology Blotting, Western Cell Line Chemokine CCL5 - genetics Cytokines Cytokines - genetics Enzyme Inhibitors - pharmacology Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Farms FasL protein Gene Expression - drug effects Health aspects Health risks Hogs Humans Infection Inflammation Influenza Influenza A Virus, H1N1 Subtype - isolation & purification Influenza A Virus, H1N1 Subtype - physiology Influenza viruses Inhibition Interferon Interleukin 10 Interleukin 6 Interleukin 8 JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases Livestock Lungs Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - virology MAP kinase Medicine Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase 9 - metabolism Mitogens NF-kappa B - metabolism NF-κB protein Orthomyxoviridae Infections - epidemiology Orthomyxoviridae Infections - veterinary Pandemics Pathogenesis Phosphotransferases Pork industry Public health RANTES Respiratory diseases Reverse Transcriptase Polymerase Chain Reaction Swine Swine Diseases - epidemiology Swine Diseases - virology Swine flu Swine influenza Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α Veterinary colleges Veterinary Science Virulence (Microbiology) Viruses
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