Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma

The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongl...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30215-e30215
Hauptverfasser:	Saha, Manujendra N, Jiang, Hua, Yang, Yijun, Zhu, Xiaoyun, Wang, Xiaoming, Schimmer, Aaron D, Qiu, Lugui, Chang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Analysis Angiogenesis Apoptosis Apoptosis - drug effects Binding sites Biology c-Jun protein Cancer Cell Line Cell Line, Tumor Cell Survival - drug effects Cellular biology Chromatin Chromatin Immunoprecipitation Cytotoxicity Dexamethasone Disruption DNA microarrays Drugs Feedback loops Furans - pharmacology Gene expression Genes Genetic aspects Genotoxicity Health care networks Hematology Hospitals Humans Immunoblotting Immunoprecipitation In Vitro Techniques Inhibition Inhibitors JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases Laboratories Leukemia Life sciences Medical research Medicine Molecular modelling Multiple myeloma Multiple Myeloma - metabolism Mutation NMR Nuclear magnetic resonance p53 Protein Phosphorylation Positive feedback Protein binding Proteins Real-Time Polymerase Chain Reaction Ribonucleic acid RNA Signal transduction Signal Transduction - drug effects Signaling siRNA Substance abuse treatment Transcription activation Transcription factors Tumor cells Tumor proteins Tumor Suppressor Protein p53 - metabolism
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