Genetic signatures of exceptional longevity in humans

Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity in 801 centenarians...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e29848
Hauptverfasser:	Sebastiani, Paola, Solovieff, Nadia, Dewan, Andrew T, Walsh, Kyle M, Puca, Annibale, Hartley, Stephen W, Melista, Efthymia, Andersen, Stacy, Dworkis, Daniel A, Wilk, Jemma B, Myers, Richard H, Steinberg, Martin H, Montano, Monty, Baldwin, Clinton T, Hoh, Josephine, Perls, Thomas T
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Aging Aging - genetics Alleles Analysis Apolipoprotein E Bayes Theorem Biology Centenarians Chromosomes Chronic illnesses Classification Cluster analysis Cohort Studies Conditional probability Death Female Gene Frequency Genetic aspects Genetic factors Genetic Predisposition to Disease - genetics Genome, Human - genetics Genome-wide association studies Genomes Genomics Genotype Geriatrics Health risk assessment Humans Indexing Longevity Longevity - genetics Male Mathematics Model accuracy Models, Genetic Models, Statistical Mortality Polymorphism, Single Nucleotide Sensitivity Signatures Single nucleotide polymorphisms Single-nucleotide polymorphism
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