Bioenergetics failure and oxidative stress in brain stem mediates cardiovascular collapse associated with fatal methamphetamine intoxication

Whereas sudden death, most often associated with cardiovascular collapse, occurs in abusers of the psychostimulant methamphetamine (METH), the underlying mechanism is much less understood. The demonstration that successful resuscitation of an arrested heart depends on maintained functionality of the...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30589
Hauptverfasser:	Li, Faith C H, Yen, Jiin-Cherng, Chan, Samuel H H, Chang, Alice Y W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anions Anoxia Antioxidants Apoptosis Autophagy Bioenergetics Biology Blood Blood flow Blood pressure Blood Pressure - drug effects Blood-brain barrier Brain Brain death Brain research Brain stem Brain Stem - drug effects Brain Stem - metabolism Cardiovascular system Cell death Cell Hypoxia - drug effects Chain mobility Chains Coenzyme Q10 Collapse Drug dosages Electron transport Energy Metabolism - drug effects Enzymatic activity Enzyme activity Enzymes Failure Gangrene Heart rate Heart Rate - drug effects Hypotheses Hypoxia Intoxication Intravenous administration Laboratories Male Medical prognosis Medicine Medulla oblongata Methamphetamine Methamphetamine - toxicity Microinjection Microvasculature Mitochondria Mortality Oxidative stress Oxidative Stress - drug effects Perfusion Physiological aspects Poisoning Poisons Rats Rats, Sprague-Dawley Regulation Resuscitation Rodents Superoxide Superoxides
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