Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery

5-Fluorouracil (5-FU) is a cytostatic drug associated with chemotherapy-induced cognitive impairments that many cancer patients experience after treatment. Previous work in rodents has shown that 5-FU reduces hippocampal cell proliferation, a possible mechanism for the observed cognitive impairment,...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30010
Hauptverfasser:	Lyons, Laura, ElBeltagy, Maha, Bennett, Geoffrey, Wigmore, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Animal behavior Animal cognition Animals Antidepressants Antidepressive Agents, Second-Generation - pharmacology Antimetabolites, Antineoplastic - adverse effects Apoptosis Biology Body Weight - drug effects Brain Brain research Bromodeoxyuridine - metabolism Cancer Cell cycle Cell growth Cell proliferation Cell Proliferation - drug effects Cell survival Chemo brain Chemotherapy Cognition Disorders - chemically induced Cognition Disorders - prevention & control Cognitive ability Dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - metabolism Dentate Gyrus - pathology Drinking - drug effects Drinking water Emotional disorders Experiments Fluorouracil Fluorouracil - adverse effects Fluoxetine Fluoxetine - pharmacology Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Immunohistochemistry Impairment Ki-67 Antigen - metabolism Kinases Laboratory animals Lymphoma Male Medicine Memory Memory - drug effects Memory tasks Neurogenesis Pancreatic cancer Patients Prevention Proteins Rats Recovery Recovery (Medical) Rodentia Rodents Serotonin Social and Behavioral Sciences Space Perception - drug effects Spatial analysis Spatial memory Stem cells Studies Survival Time Factors Weight Gain - drug effects
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