Stem cells propagate their DNA by random segregation in the flatworm Macrostomum lignano

Adult stem cells are proposed to have acquired special features to prevent an accumulation of DNA-replication errors. Two such mechanisms, frequently suggested to serve this goal are cellular quiescence, and non-random segregation of DNA strands during stem cell division, a theory designated as the...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e30227
Hauptverfasser:	Verdoodt, Freija, Willems, Maxime, Mouton, Stijn, De Mulder, Katrien, Bert, Wim, Houthoofd, Wouter, Smith, 3rd, Julian, Ladurner, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Actin Adults Animals Biology Cell cycle Cell division Cell Division - drug effects Cell Division - genetics Cell Division - physiology Cell growth Chromosome Segregation - drug effects Chromosome Segregation - genetics Cytochalasin D Cytochalasin D - pharmacology Deoxyribonucleic acid Divisions DNA DNA - genetics DNA - metabolism DNA biosynthesis Dugesia Genetic research Genomes Hypotheses Immunohistochemistry In vivo methods and tests Labeling Labelling Laboratories Macrostomida Macrostomum Morphogenesis Platyhelminthes Platyhelminths - genetics Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - drug effects Pluripotent Stem Cells - metabolism Retention Senescence Sperm Stem cell research Stem cell transplantation Stem cells Strands Turbellaria
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