Discovery of T cell antigens by high-throughput screening of synthetic minigene libraries

The identification of novel T cell antigens is central to basic and translational research in autoimmunity, tumor immunology, transplant immunology, and vaccine design for infectious disease. However, current methods for T cell antigen discovery are low throughput, and fail to explore a wide range o...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e29949-e29949
Hauptverfasser:	Hondowicz, Brian D, Schwedhelm, Katharine V, Kas, Arnold, Tasch, Michael A, Rawlings, Crystal, Ramchurren, Nirasha, McIntosh, Martin, D'Amico, Leonard A, Sanda, Srinath, Standifer, Nathan E, Shendure, Jay, Stone, Brad
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigen-presenting cells Antigens Antigens - immunology Antigens, Neoplasm - chemistry Antigens, Neoplasm - immunology Autoantigens Autografts Autoimmune diseases Autoimmunity B cells Biology Cancer Case-Control Studies CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - immunology Consortia Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - immunology DNA Enzyme-linked immunosorbent assay Enzyme-Linked Immunospot Assay Epithelial Cell Adhesion Molecule Epitopes - chemistry Epitopes - immunology Error correction & detection Gene Library Genes Genomes High-throughput screening High-Throughput Screening Assays - methods HLA Antigens - immunology Human subjects Humans Immune system Immunology Infectious diseases Libraries Lymphocytes Lymphocytes T Medical research Medicine Molecular Sequence Data mRNA Neoplasm Proteins - chemistry Neoplasm Proteins - immunology Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - immunology Optimization Pancreas Peptides Peripheral blood Population Protein Binding Researchers RNA Screening T cell receptors T cells T-Lymphocytes - immunology Transgenic animals Vaccines
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