Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse

Increased utrophin expression is known to reduce pathology in dystrophin-deficient skeletal muscles. Transgenic over-expression of PGC-1α has been shown to increase levels of utrophin mRNA and improve the histology of mdx muscles. Other reports have shown that PGC-1α signaling can lead to increased...

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Veröffentlicht in:	PloS one 2012, Vol.7 (1), p.e30063-e30063
Hauptverfasser:	Selsby, Joshua T, Morine, Kevin J, Pendrak, Klara, Barton, Elisabeth R, Sweeney, H Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Biomechanical Phenomena Body Weight - drug effects Contraction Crack propagation Dependovirus - drug effects Dependovirus - metabolism Dietary Supplements Dystrophin Fatigue Fatigue failure Fatigue strength Fibers Gene expression Gene therapy Gene Transfer Techniques Glycoproteins Histology Insulin-like growth factors Localization Medicine Mice Mice, Inbred mdx Mitochondria mRNA Muscle Contraction Muscle Fatigue Muscle Fibers, Fast-Twitch - drug effects Muscle Fibers, Fast-Twitch - pathology Muscle Fibers, Slow-Twitch - drug effects Muscle Fibers, Slow-Twitch - pathology Muscle function Muscles Muscular dystrophy Muscular Dystrophy, Animal - complications Muscular Dystrophy, Animal - physiopathology Musculoskeletal system Myosin Myosins - metabolism Neonates Organ Size Overexpression Oxidation resistance Oxidative stress Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Pharmacology Phosphorylation Physiology Proteins Recovery of Function - drug effects Recovery of Function - physiology Resveratrol Rodents Signal transduction Signaling Skeletal muscle Stilbenes - administration & dosage Stilbenes - pharmacology Trans-Activators - metabolism Transcription Factors Transgenic Utrophin Viruses
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