Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm

In higher eukaryotes, PAPS synthases are the only enzymes producing the essential sulphate-donor 3'-phospho-adenosine-5'-phosphosulphate (PAPS). Recently, PAPS synthases have been associated with several genetic diseases and retroviral infection. To improve our understanding of their patho...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e29559
Hauptverfasser:	Schröder, Elisabeth, Gebel, Lena, Eremeev, Andrey A, Morgner, Jessica, Grum, Daniel, Knauer, Shirley K, Bayer, Peter, Mueller, Jonathan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Adenosine Amino Acid Motifs Amino Acid Sequence Animals Apoptosis Biochemistry Biology Biotechnology Cell Nucleus - drug effects Cell Nucleus - enzymology Conserved Sequence - genetics Cytoplasm Cytosol - enzymology Deoxyribonucleic acid DNA Enzymes Eukaryotes Exportin 1 Protein Exports Fatty Acids, Unsaturated - pharmacology Genetic aspects Green Fluorescent Proteins - metabolism Health aspects HeLa Cells HIV Hominidae Human immunodeficiency virus Humans Infections International trade Isoenzymes - chemistry Isoenzymes - metabolism Isoforms Karyopherins - metabolism Kinases Leptomycin B Localization Mice Microinjection Molecular biology Molecular Sequence Data Molecular Weight Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Mutagenesis Mutagenesis - drug effects Mutant Proteins - chemistry Mutant Proteins - metabolism Mutation - genetics Nuclear Export Signals - drug effects Nuclear Localization Signals - chemistry Nuclear transport Nuclei Pattern recognition Physics Protein Transport - drug effects Proteins Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Fusion Proteins - metabolism Subcellular Fractions - drug effects Subcellular Fractions - enzymology Sulfate Adenylyltransferase - chemistry Sulfate Adenylyltransferase - metabolism
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