The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi

G protein-coupled receptors (GPCRs) in humans are classified into the five main families named Glutamate, Rhodopsin, Adhesion, Frizzled and Secretin according to the GRAFS classification. Previous results show that these mammalian GRAFS families are well represented in the Metazoan lineages, but the...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e29817-e29817
Hauptverfasser:	Krishnan, Arunkumar, Almén, Markus Sällman, Fredriksson, Robert, Schiöth, Helgi B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Algorithms Amino Acid Sequence Amino acids Amoebozoa Animals Bioinformatics Biology Cell Adhesion Molecules - genetics Cell Adhesion Molecules - isolation & purification Cloning, Molecular Cyclic adenosine monophosphate Cyclic AMP Datasets Evolution, Molecular Filasterea Frizzled protein Frizzled Receptors - genetics Frizzled Receptors - isolation & purification Fungi Fungi - genetics Fungi - physiology G protein-coupled receptors Genes, Fungal Genome, Fungal Genomes Genomics Glutamate Glutamic acid receptors Humans Hypotheses Ligands Mammals Mammals - genetics Metazoa Molecular Sequence Data Nematoda Neurosciences Paramecium Peptides Pharmacology Pheromones Phylogenetics Phylogeny Placozoa Proteins Receptors Receptors, G-Protein-Coupled - classification Receptors, G-Protein-Coupled - genetics Receptors, Glutamate - genetics Receptors, Glutamate - isolation & purification Rhodopsin Rhodopsin - genetics Rhodopsin - isolation & purification Secretin Tetrahymena thermophila Trends Vertebrates
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