Class IA PI3Kinase Regulatory Subunit, p85α, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes

Stem cell factor (SCF) mediated KIT receptor activation plays a pivotal role in mast cell growth, maturation and survival. However, the signaling events downstream from KIT are poorly understood. Mast cells express multiple regulatory subunits of class 1A PI3Kinase (PI3K) including p85α, p85β, p50α,...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e28979
Hauptverfasser:	Krishnan, Subha, Mali, Raghuveer Singh, Koehler, Karl R., Vemula, Sasidhar, Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Ma, Peilin, Hashino, Eri, Kapur, Reuben
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Angiogenesis Apoptosis Bioinformatics Biology Bone marrow Breast cancer Cardiovascular disease Cell adhesion Cell cycle Cell differentiation Cell growth Cell survival Cycles Cytokines Differentiation (biology) DNA microarrays Gene expression Genes Growth factors Hypoglycemia Incorporation Inflammatory diseases Kinases Mast cells Medical research Medicine Metastasis Motility Pediatrics Receptor mechanisms Regulatory subunits Signal transduction Signaling Software Stem cell factor Stem cells Stimulation Survival Transcription
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