Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion

Expansion of hematopoietic stem/progenitor cells (HSPCs) is a well-known strategy employed to facilitate the transplantation outcome. We have previously shown that the prevention of apoptosis by the inhibition of cysteine proteases, caspase and calpain played an important role in the expansion and e...

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Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e29383
Hauptverfasser:	Sangeetha, V M, Kadekar, Darshana, Kale, Vaijayanti P, Limaye, Lalita S
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - chemistry Adhesion tests Adhesives Amino Acid Chloromethyl Ketones - pharmacology Analysis Animals Apoptosis Biology Blood Bone marrow Bone marrow transplantation Calpain Calpain - antagonists & inhibitors Caspase Inhibitors CD34 antigen Cell adhesion Cell Adhesion - drug effects Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell cycle Cell Movement - drug effects Cell Polarity - drug effects Cell Size - drug effects Cells (biology) Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Chemokines College campuses Cord blood CXCR4 protein Cysteine Cytokines Expansion Female Fetal Blood - cytology Flow cytometry Gene Expression Regulation - drug effects Growth factors Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Homing Humans Inhibition Integrin alpha4 - metabolism Integrin alpha5 - metabolism Integrins Kinases Laboratories Medicine Mice Muscle proteins Pharmacology Polymerization Population Priming Progenitor cells Protease inhibitors Protease Inhibitors - pharmacology Protein Multimerization - drug effects Protein Structure, Quaternary Proteinase inhibitors Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism rho GTP-Binding Proteins - metabolism Standard deviation Stem cells Transplantation Transplants & implants
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