Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases

Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-01, Vol.7 (1), p.e29161-e29161
Hauptverfasser:	Wong, David, Kea, Bory, Pesich, Rob, Higgs, Brandon W, Zhu, Wei, Brown, Patrick, Yao, Yihong, Fiorentino, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Acne Adult Antigens Arthritis Atopic dermatitis Autoimmune diseases B cells Baldness Biochemistry Biological activity Biological response modifiers Biology Biopsy Biosynthesis Case-Control Studies Cluster analysis Comparative analysis Complement activation Contact dermatitis Cytotoxicity Dendritic cells Dermatitis Dermatology Dermatomyositis Dermatomyositis - genetics Dermatomyositis - pathology Disease Eczema Gangrene Gene expression Genes Genetic Markers - genetics Genomes Genomics Health aspects Herpes simplex Heterogeneity Humans Inflammation Inflammatory diseases Interferon Interferons - genetics Lungs Lupus Lymphocytes Medicine Messenger RNA Middle Aged Muscles Oligonucleotide Array Sequence Analysis Pathogenesis Psoriasis Quantitation Scleroderma Scleroderma (Disease) Signatures Skin Skin diseases Systemic sclerosis Transcription Transcriptome - genetics β-Interferon γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!