Acute hypoglycemia induces retinal cell death in mouse

Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Glycemic excursions could lead to cardiovascular disease, nephropathy, neuropathy and retinopathy. A vast body of literature exists on hyperglycemia namel...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21586-e21586
Hauptverfasser:	Emery, Martine, Schorderet, Daniel F, Roduit, Raphaël
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Triphosphate - metabolism Analysis Animals Antioxidants Apoptosis Apoptosis - physiology Biochemistry Biology Blotting, Western Brain research Cardiovascular diseases Carrier Proteins - genetics Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Cell culture Cell cycle Cell death Cell Death - physiology Cells, Cultured Complementation Diabetes Diabetes mellitus Diabetes therapy Diabetic neuropathy Diabetic retinopathy Eye diseases Female Flow Cytometry Gangrene Gene expression Gene regulation Genes Glucose Glutathione Glutathione - metabolism Glutathione peroxidase Glutathione Peroxidase - genetics Glutathione transferase Glutathione Transferase - genetics Growth factors Homeostasis Hyperglycemia Hyperglycemia - physiopathology Hypoglycemia Hypoxia In Vitro Techniques In vivo methods and tests Insulin Mice Mice, Inbred C57BL Mortality Nephropathy Neuropathy Peroxidase Photoreceptors Proteins Retina Retina - cytology Retina - metabolism Retina - pathology Retinopathy Reverse Transcriptase Polymerase Chain Reaction Signal transduction Superoxide Superoxides
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