Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression

BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'UTR) in the BACE1 promoter. BACE1 expression is activated by phosphor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21456-e21456
Hauptverfasser:	Ill-Raga, Gerard, Palomer, Ernest, Wozniak, Matthew A, Ramos-Fernández, Eva, Bosch-Morató, Mònica, Tajes, Marta, Guix, Francesc X, Galán, José J, Clarimón, Jordi, Antúnez, Carmen, Real, Luis M, Boada, Mercé, Itzhaki, Ruth F, Fandos, César, Muñoz, Francisco J
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Aged Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animals Apolipoprotein E Apolipoproteins Apoptosis Biology Blotting, Western Brain Cell Line Cell Line, Tumor Cell Survival - genetics Cell Survival - physiology Cloning Cytokines Double-stranded RNA E protein eIF-2 kinase eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Enzymes Female Gene expression Genes Genomes Health aspects Health sciences HeLa Cells Herpes simplex Herpes viruses Herpesvirus 1, Human - physiology Hospitals Humans Immunohistochemistry In Vitro Techniques Infection Interferon Kinases Laboratories Medicine Mice Mice, Inbred BALB C Neuroblastoma Neuroblastoma cells Neurodegenerative diseases Peptides Phosphatases Phosphorylation Physiology Protein kinase Protein kinases Proteins Ribonucleic acid RNA Viral infections Viruses β-Amyloid β-Site APP-cleaving enzyme 1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!